2gwk

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[[Image:2gwk.gif|left|200px]]
[[Image:2gwk.gif|left|200px]]
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{{Structure
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|PDB= 2gwk |SIZE=350|CAPTION= <scene name='initialview01'>2gwk</scene>, resolution 2.000&Aring;
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The line below this paragraph, containing "STRUCTURE_2gwk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATP:ADENOSINE-5&#39;-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=HIC:4-METHYL-HISTIDINE'>HIC</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2gwk| PDB=2gwk | SCENE= }}
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|RELATEDENTRY=[[2gwj|2GWJ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gwk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gwk OCA], [http://www.ebi.ac.uk/pdbsum/2gwk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gwk RCSB]</span>
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}}
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'''SpvB ADP-ribosylated actin: orthorhombic crystal form'''
'''SpvB ADP-ribosylated actin: orthorhombic crystal form'''
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[[Category: Margarit, S M.]]
[[Category: Margarit, S M.]]
[[Category: Stebbins, C E.]]
[[Category: Stebbins, C E.]]
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[[Category: actin]]
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[[Category: Actin]]
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[[Category: adp-ribosylation]]
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[[Category: Adp-ribosylation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:37:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:36 2008''
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Revision as of 02:37, 4 May 2008

Image:2gwk.gif

Template:STRUCTURE 2gwk

SpvB ADP-ribosylated actin: orthorhombic crystal form


Overview

Salmonella spp. require the ADP-ribosyltransferase activity of the SpvB protein for intracellular growth and systemic virulence. SpvB covalently modifies actin, causing cytoskeletal disruption and apoptosis. We report here the crystal structure of the catalytic domain of SpvB, and we show by mass spectrometric analysis that SpvB modifies actin at Arg177, inhibiting its ATPase activity. We also describe two crystal structures of SpvB-modified, polymerization-deficient actin. These structures reveal that ADP-ribosylation does not lead to dramatic conformational changes in actin, suggesting a model in which this large family of toxins inhibits actin polymerization primarily through steric disruption of intrafilament contacts.

About this Structure

2GWK is a Single protein structure of sequence from Oryctolagus cuniculus. Full crystallographic information is available from OCA.

Reference

A steric antagonism of actin polymerization by a salmonella virulence protein., Margarit SM, Davidson W, Frego L, Stebbins CE, Structure. 2006 Aug;14(8):1219-29. PMID:16905096 Page seeded by OCA on Sun May 4 05:37:31 2008

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