2gxb

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[[Image:2gxb.gif|left|200px]]
[[Image:2gxb.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gxb |SIZE=350|CAPTION= <scene name='initialview01'>2gxb</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_2gxb", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=DU:2&#39;-DEOXYURIDINE-5&#39;-MONOPHOSPHATE'>DU</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= ADAR, ADAR1, DSRAD, IFI4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2gxb| PDB=2gxb | SCENE= }}
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|RELATEDENTRY=[[1qbj|1QBJ]], [[1xmk|1XMK]], [[1qjp|1QJP]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gxb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gxb OCA], [http://www.ebi.ac.uk/pdbsum/2gxb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gxb RCSB]</span>
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}}
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'''Crystal Structure of The Za Domain bound to Z-RNA'''
'''Crystal Structure of The Za Domain bound to Z-RNA'''
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[[Category: Placido, D.]]
[[Category: Placido, D.]]
[[Category: Rich, A.]]
[[Category: Rich, A.]]
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[[Category: adar1]]
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[[Category: Adar1]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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[[Category: rna editing]]
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[[Category: Rna editing]]
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[[Category: z-rna]]
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[[Category: Z-rna]]
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[[Category: za]]
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[[Category: Za]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:38:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:22:50 2008''
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Revision as of 02:38, 4 May 2008

Image:2gxb.gif

Template:STRUCTURE 2gxb

Crystal Structure of The Za Domain bound to Z-RNA


Overview

The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.

About this Structure

2GXB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712 Page seeded by OCA on Sun May 4 05:38:42 2008

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