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2gxb
From Proteopedia
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'''Crystal Structure of The Za Domain bound to Z-RNA''' | '''Crystal Structure of The Za Domain bound to Z-RNA''' | ||
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[[Category: Placido, D.]] | [[Category: Placido, D.]] | ||
[[Category: Rich, A.]] | [[Category: Rich, A.]] | ||
| - | [[Category: | + | [[Category: Adar1]] |
| - | [[Category: | + | [[Category: Protein-rna complex]] |
| - | [[Category: | + | [[Category: Rna editing]] |
| - | [[Category: | + | [[Category: Z-rna]] |
| - | [[Category: | + | [[Category: Za]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:38:42 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 02:38, 4 May 2008
Crystal Structure of The Za Domain bound to Z-RNA
Overview
The A form RNA double helix can be transformed to a left-handed helix, called Z-RNA. Currently, little is known about the detailed structural features of Z-RNA or its involvement in cellular processes. The discovery that certain interferon-response proteins have domains that can stabilize Z-RNA as well as Z-DNA opens the way for the study of Z-RNA. Here, we present the 2.25 A crystal structure of the Zalpha domain of the RNA-editing enzyme ADAR1 (double-stranded RNA adenosine deaminase) complexed to a dUr(CG)(3) duplex RNA. The Z-RNA helix is associated with a unique solvent pattern that distinguishes it from the otherwise similar conformation of Z-DNA. Based on the structure, we propose a model suggesting how differences in solvation lead to two types of Z-RNA structures. The interaction of Zalpha with Z-RNA demonstrates how the interferon-induced isoform of ADAR1 could be targeted toward selected dsRNAs containing purine-pyrimidine repeats, possibly of viral origin.
About this Structure
2GXB is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
A left-handed RNA double helix bound by the Z alpha domain of the RNA-editing enzyme ADAR1., Placido D, Brown BA 2nd, Lowenhaupt K, Rich A, Athanasiadis A, Structure. 2007 Apr;15(4):395-404. PMID:17437712 Page seeded by OCA on Sun May 4 05:38:42 2008
Categories: Homo sapiens | Single protein | Athanasiadis, A. | Placido, D. | Rich, A. | Adar1 | Protein-rna complex | Rna editing | Z-rna | Za
