2gz2

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[[Image:2gz2.gif|left|200px]]
[[Image:2gz2.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2gz2 |SIZE=350|CAPTION= <scene name='initialview01'>2gz2</scene>, resolution 2.100&Aring;
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The line below this paragraph, containing "STRUCTURE_2gz2", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:A2p+Binding+Site+For+Residue+B+501'>AC1</scene> and <scene name='pdbsite=AC2:A2p+Binding+Site+For+Residue+A+502'>AC2</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=A2P:ADENOSINE-2&#39;-5&#39;-DIPHOSPHATE'>A2P</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aspartate-semialdehyde_dehydrogenase Aspartate-semialdehyde dehydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.2.1.11 1.2.1.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= asd ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1313 Streptococcus pneumoniae])
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-->
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|DOMAIN=
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{{STRUCTURE_2gz2| PDB=2gz2 | SCENE= }}
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|RELATEDENTRY=[[2gz1|2GZ1]], [[2gyy|2GYY]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2gz2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2gz2 OCA], [http://www.ebi.ac.uk/pdbsum/2gz2 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2gz2 RCSB]</span>
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}}
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'''Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with 2',5'-ADP'''
'''Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with 2',5'-ADP'''
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[[Category: Liu, X.]]
[[Category: Liu, X.]]
[[Category: Viola, R E.]]
[[Category: Viola, R E.]]
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[[Category: aspartate pathway]]
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[[Category: Aspartate pathway]]
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[[Category: dehydrogenase]]
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[[Category: Dehydrogenase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:40:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:23:11 2008''
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Revision as of 02:40, 4 May 2008

Image:2gz2.gif

Template:STRUCTURE 2gz2

Structure of Aspartate Semialdehyde Dehydrogenase (ASADH) from Streptococcus pneumoniae complexed with 2',5'-ADP


Overview

Aspartate-beta-semialdehyde dehydrogenase (ASADH) catalyzes a critical branch point transformation in amino acid bio-synthesis. The products of the aspartate pathway are essential in microorganisms, and this entire pathway is absent in mammals, making this enzyme an attractive target for antibiotic development. The first structure of an ASADH from a Gram-positive bacterium, Streptococcus pneumoniae, has now been determined. The overall structure of the apoenzyme has a similar fold to those of the Gram-negative and archaeal ASADHs but contains some interesting structural variations that can be exploited for inhibitor design. Binding of the coenzyme NADP, as well as a truncated nucleotide analogue, into an alternative conformation from that observed in Gram-negative ASADHs causes an enzyme domain closure that precedes catalysis. The covalent acyl-enzyme intermediate was trapped by soaking the substrate into crystals of the coenzyme complex, and the structure of this elusive intermediate provides detailed insights into the catalytic mechanism.

About this Structure

2GZ2 is a Single protein structure of sequence from Streptococcus pneumoniae. Full crystallographic information is available from OCA.

Reference

Examination of key intermediates in the catalytic cycle of aspartate-beta-semialdehyde dehydrogenase from a gram-positive infectious bacteria., Faehnle CR, Le Coq J, Liu X, Viola RE, J Biol Chem. 2006 Oct 13;281(41):31031-40. Epub 2006 Aug 8. PMID:16895909 Page seeded by OCA on Sun May 4 05:40:22 2008

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OCA

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