2oot
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(New page: 200px<br /> <applet load="2oot" size="450" color="white" frame="true" align="right" spinBox="true" caption="2oot, resolution 1.64Å" /> '''A High Resolution S...)
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Revision as of 21:07, 12 November 2007
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A High Resolution Structure of Ligand-free Human Glutamate Carboxypeptidase II
Contents |
Overview
Human glutamate carboxypeptidase II (GCPII; EC 3.4.17.21) is an, established marker for prostate-cancer diagnosis as well as a candidate, therapeutic target for the treatment of diverse pathologies that involve, glutamatergic transmission. Structural data on GCPII are thus valuable for, the design and optimization of GCPII-specific inhibitors and diagnostic, probes. The currently available structure of ligand-free GCPII was refined, to a resolution of 3.5 A. This work reports the structure of the protein, refined to 1.65 A resolution, with crystallographic values of R = 0.207, and R(free) = 0.228. The new structure extends the resolution appreciably, and the new model based on this data shows significant differences when, compared with the previously published model.
Disease
Known diseases associated with this structure: Myocardial infarcation, susceptibility to OMIM:[602855]
About this Structure
2OOT is a Single protein structure of sequence from Homo sapiens with NAG, ZN, CA and CL as ligands. Active as Glutamate carboxypeptidase II, with EC number 3.4.17.21 Full crystallographic information is available from OCA.
Reference
A high-resolution structure of ligand-free human glutamate carboxypeptidase II., Barinka C, Starkova J, Konvalinka J, Lubkowski J, Acta Crystallograph Sect F Struct Biol Cryst Commun. 2007 Mar 1;63(Pt, 3):150-3. Epub 2007 Feb 13. PMID:17329803
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