2h0p
From Proteopedia
Line 1: | Line 1: | ||
[[Image:2h0p.gif|left|200px]] | [[Image:2h0p.gif|left|200px]] | ||
- | + | <!-- | |
- | + | The line below this paragraph, containing "STRUCTURE_2h0p", creates the "Structure Box" on the page. | |
- | + | You may change the PDB parameter (which sets the PDB file loaded into the applet) | |
- | + | or the SCENE parameter (which sets the initial scene displayed when the page is loaded), | |
- | | | + | or leave the SCENE parameter empty for the default display. |
- | | | + | --> |
- | + | {{STRUCTURE_2h0p| PDB=2h0p | SCENE= }} | |
- | + | ||
- | + | ||
- | }} | + | |
'''NMR Structure of the Dengue-4 virus Envelope Protein Domain III''' | '''NMR Structure of the Dengue-4 virus Envelope Protein Domain III''' | ||
Line 31: | Line 28: | ||
[[Category: Thiviyanathan, V.]] | [[Category: Thiviyanathan, V.]] | ||
[[Category: Volk, D E.]] | [[Category: Volk, D E.]] | ||
- | [[Category: | + | [[Category: Beta sandwich]] |
- | [[Category: | + | [[Category: Ig-fold]] |
- | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:51 2008'' | |
- | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + |
Revision as of 02:43, 4 May 2008
NMR Structure of the Dengue-4 virus Envelope Protein Domain III
Overview
The disease dengue (DEN) is caused by four serologically related viruses termed DEN1, DEN2, DEN3 and DEN4. The structure of the ectodomain of the envelope protein has been determined previously for DEN2 and DEN3 viruses. Using NMR spectroscopic methods, we solved the solution structure of domain III (ED3), the receptor-binding domain, of the envelope protein of DEN4 virus, human strain 703-4. The structure shows that the nine amino acid changes in ED3 that separate the sylvatic and human DEN4 strains are surface exposed. Important structural differences between DEN4-rED3 and ED3 domains of DEN2, DEN3 and other flaviviruses are discussed.
About this Structure
2H0P is a Single protein structure of sequence from Dengue virus 4. Full crystallographic information is available from OCA.
Reference
Solution structure of the envelope protein domain III of dengue-4 virus., Volk DE, Lee YC, Li X, Thiviyanathan V, Gromowski GD, Li L, Lamb AR, Beasley DW, Barrett AD, Gorenstein DG, Virology. 2007 Jul 20;364(1):147-54. Epub 2007 Mar 29. PMID:17395234 Page seeded by OCA on Sun May 4 05:43:51 2008