2h0q

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[[Image:2h0q.jpg|left|200px]]
[[Image:2h0q.jpg|left|200px]]
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{{Structure
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|PDB= 2h0q |SIZE=350|CAPTION= <scene name='initialview01'>2h0q</scene>, resolution 1.82&Aring;
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The line below this paragraph, containing "STRUCTURE_2h0q", creates the "Structure Box" on the page.
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|SITE=
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|GENE= STS-1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_2h0q| PDB=2h0q | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h0q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h0q OCA], [http://www.ebi.ac.uk/pdbsum/2h0q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h0q RCSB]</span>
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'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''
'''Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)'''
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[[Category: Ford, B.]]
[[Category: Ford, B.]]
[[Category: Nassar, N.]]
[[Category: Nassar, N.]]
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[[Category: pgm]]
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[[Category: Pgm]]
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[[Category: signaling protein]]
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[[Category: Signaling protein]]
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[[Category: sts-1]]
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[[Category: Sts-1]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:43:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:23:50 2008''
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Revision as of 02:43, 4 May 2008

Image:2h0q.jpg

Template:STRUCTURE 2h0q

Crystal Structure of the PGM domain of the Suppressor of T-Cell receptor (Sts-1)


Overview

Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.

About this Structure

2H0Q is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.

Reference

A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096 Page seeded by OCA on Sun May 4 05:43:53 2008

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