2h5x

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[[Image:2h5x.gif|left|200px]]
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{{Structure
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|PDB= 2h5x |SIZE=350|CAPTION= <scene name='initialview01'>2h5x</scene>, resolution 2.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2h5x", creates the "Structure Box" on the page.
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|SITE=
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|GENE= ruvA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1773 Mycobacterium tuberculosis])
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{{STRUCTURE_2h5x| PDB=2h5x | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h5x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h5x OCA], [http://www.ebi.ac.uk/pdbsum/2h5x PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h5x RCSB]</span>
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'''RuvA from Mycobacterium tuberculosis'''
'''RuvA from Mycobacterium tuberculosis'''
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[[Category: Waldo, G S.]]
[[Category: Waldo, G S.]]
[[Category: Yu, M.]]
[[Category: Yu, M.]]
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[[Category: holliday junction binding]]
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[[Category: Holliday junction binding]]
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[[Category: recombination]]
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[[Category: Recombination]]
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[[Category: ruva]]
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[[Category: Ruva]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:54:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:25:52 2008''
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Revision as of 02:54, 4 May 2008

Image:2h5x.gif

Template:STRUCTURE 2h5x

RuvA from Mycobacterium tuberculosis


Overview

The process of recombinational repair is crucial for maintaining genomic integrity and generating biological diversity. In association with RuvB and RuvC, RuvA plays a central role in processing and resolving Holliday junctions, which are a critical intermediate in homologous recombination. Here, the cloning, purification and structure determination of the RuvA protein from Mycobacterium tuberculosis (MtRuvA) are reported. Analysis of the structure and comparison with other known RuvA proteins reveal an octameric state with conserved subunit-subunit interaction surfaces, indicating the requirement of octamer formation for biological activity. A detailed analysis of plasticity in the RuvA molecules has led to insights into the invariant and variable regions, thus providing a framework for understanding regional flexibility in various aspects of RuvA function.

About this Structure

2H5X is a Single protein structure of sequence from Mycobacterium tuberculosis. Full crystallographic information is available from OCA.

Reference

Structure of Mycobacterium tuberculosis RuvA, a protein involved in recombination., Prabu JR, Thamotharan S, Khanduja JS, Alipio EZ, Kim CY, Waldo GS, Terwilliger TC, Segelke B, Lekin T, Toppani D, Hung LW, Yu M, Bursey E, Muniyappa K, Chandra NR, Vijayan M, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Aug 1;62(Pt, 8):731-4. Epub 2006 Jul 24. PMID:16880543 Page seeded by OCA on Sun May 4 05:54:12 2008

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