2h8a

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[[Image:2h8a.jpg|left|200px]]
[[Image:2h8a.jpg|left|200px]]
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{{Structure
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|PDB= 2h8a |SIZE=350|CAPTION= <scene name='initialview01'>2h8a</scene>, resolution 3.20&Aring;
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The line below this paragraph, containing "STRUCTURE_2h8a", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=GTT:GLUTATHIONE'>GTT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione_transferase Glutathione transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.5.1.18 2.5.1.18] </span>
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|GENE=
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{{STRUCTURE_2h8a| PDB=2h8a | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2h8a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2h8a OCA], [http://www.ebi.ac.uk/pdbsum/2h8a PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2h8a RCSB]</span>
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'''Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione'''
'''Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Hebert, H.]]
[[Category: Hebert, H.]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 05:59:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:26:53 2008''
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Revision as of 02:59, 4 May 2008

Image:2h8a.jpg

Template:STRUCTURE 2h8a

Structure of Microsomal Glutathione Transferase 1 in Complex with Glutathione


Overview

Synthesis of mediators of fever, pain and inflammation as well as protection against reactive molecules and oxidative stress is a hallmark of the MAPEG superfamily (membrane associated proteins in eicosanoid and glutathione metabolism). The structure of a MAPEG member, rat microsomal glutathione transferase 1, at 3.2 A resolution, solved here in complex with glutathione by electron crystallography, defines the active site location and a cytosolic domain involved in enzyme activation. The glutathione binding site is found to be different from that of the canonical soluble glutathione transferases. The architecture of the homotrimer supports a catalytic mechanism involving subunit interactions and reveals both cytosolic and membraneous substrate entry sites, providing a rationale for the membrane location of the enzyme.

About this Structure

2H8A is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis for detoxification and oxidative stress protection in membranes., Holm PJ, Bhakat P, Jegerschold C, Gyobu N, Mitsuoka K, Fujiyoshi Y, Morgenstern R, Hebert H, J Mol Biol. 2006 Jul 28;360(5):934-45. Epub 2006 Jun 5. PMID:16806268 Page seeded by OCA on Sun May 4 05:59:06 2008

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