2hc4

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[[Image:2hc4.jpg|left|200px]]
[[Image:2hc4.jpg|left|200px]]
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{{Structure
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|PDB= 2hc4 |SIZE=350|CAPTION= <scene name='initialview01'>2hc4</scene>, resolution 2.2&Aring;
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The line below this paragraph, containing "STRUCTURE_2hc4", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=VDX:5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL'>VDX</scene>
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{{STRUCTURE_2hc4| PDB=2hc4 | SCENE= }}
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|RELATEDENTRY=[[1db1|1DB1]], [[2hbh|2HBH]], [[2hcd|2HCD]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hc4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hc4 OCA], [http://www.ebi.ac.uk/pdbsum/2hc4 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hc4 RCSB]</span>
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'''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''
'''Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
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[[Category: alpha helical sandwich]]
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[[Category: Alpha helical sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:06:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:21 2008''
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Revision as of 03:06, 4 May 2008

Image:2hc4.jpg

Template:STRUCTURE 2hc4

Crystal structure of the LBD of VDR of Danio rerio in complex with calcitriol


Overview

The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.

About this Structure

2HC4 is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

Reference

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092 Page seeded by OCA on Sun May 4 06:06:43 2008

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