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2hcd

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[[Image:2hcd.jpg|left|200px]]
[[Image:2hcd.jpg|left|200px]]
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{{Structure
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|LIGAND= <scene name='pdbligand=BIV:21-NOR-9,10-SECOCHOLESTA-5,7,10(19)-TRIENE-1,3,25-TRIOL,+20-(4-HYDROXY-4-METHYLPENTYL)-,+(1A,3B,5Z,7E)'>BIV</scene>
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{{STRUCTURE_2hcd| PDB=2hcd | SCENE= }}
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|RELATEDENTRY=[[1db1|1DB1]], [[2hbh|2HBH]], [[2hc4|2HC4]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hcd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hcd OCA], [http://www.ebi.ac.uk/pdbsum/2hcd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hcd RCSB]</span>
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'''Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide'''
'''Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide'''
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[[Category: Moras, D.]]
[[Category: Moras, D.]]
[[Category: Rochel, N.]]
[[Category: Rochel, N.]]
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[[Category: alpha helical sandwich]]
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[[Category: Alpha helical sandwich]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:26 2008''
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Revision as of 03:07, 4 May 2008

Image:2hcd.jpg

Template:STRUCTURE 2hcd

Crystal structure of the ligand binding domain of the Vitamin D nuclear receptor in complex with Gemini and a coactivator peptide


Overview

The crystal structure of the ligand binding domain (LBD) of the wild-type Vitamin D receptor (VDR) of zebrafish bound to Gemini, a synthetic agonist ligand with two identical side chains branching at carbon 20 reveals a ligand-dependent structural rearrangement of the ligand binding pocket (LBP). The rotation of a Leu side chain opens the access to a channel that can accommodate the second side chain of the ligand. The 25% increase of the LBP's volume does not alter the essential agonist features of VDR. The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands.

About this Structure

2HCD is a Protein complex structure of sequences from Danio rerio. Full crystallographic information is available from OCA.

Reference

Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation., Ciesielski F, Rochel N, Moras D, J Steroid Biochem Mol Biol. 2007 Mar;103(3-5):235-42. Epub 2007 Jan 10. PMID:17218092 Page seeded by OCA on Sun May 4 06:07:12 2008

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