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2hck

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[[Image:2hck.gif|left|200px]]
[[Image:2hck.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hck |SIZE=350|CAPTION= <scene name='initialview01'>2hck</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2hck", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>, <scene name='pdbligand=QUE:3,5,7,3&#39;,4&#39;-PENTAHYDROXYFLAVONE'>QUE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Transferase Transferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 and 2.7.10.2 2.7.10.1 and 2.7.10.2] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= HUMAN HCK ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2hck| PDB=2hck | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hck OCA], [http://www.ebi.ac.uk/pdbsum/2hck PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hck RCSB]</span>
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}}
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'''SRC FAMILY KINASE HCK-QUERCETIN COMPLEX'''
'''SRC FAMILY KINASE HCK-QUERCETIN COMPLEX'''
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[[Category: Moarefi, I.]]
[[Category: Moarefi, I.]]
[[Category: Sicheri, F.]]
[[Category: Sicheri, F.]]
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[[Category: protein tyrosine kinase]]
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[[Category: Protein tyrosine kinase]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: sh3]]
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[[Category: Sh3]]
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[[Category: signal transduction]]
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[[Category: Signal transduction]]
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[[Category: transferase]]
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[[Category: Transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:07:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:30 2008''
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Revision as of 03:07, 4 May 2008

Image:2hck.gif

Template:STRUCTURE 2hck

SRC FAMILY KINASE HCK-QUERCETIN COMPLEX


Overview

The crystal structure of the haematopoietic cell kinase Hck has been determined at 2.6/2.9 A resolution. Inhibition of enzymatic activity is a consequence of intramolecular interactions of the enzyme's Src-homology domains SH2 and SH3, with concomitant displacement of elements of the catalytic domain. The conformation of the active site has similarities with that of inactive cyclin-dependent protein kinases.

About this Structure

2HCK is a Single protein structure of sequence from Homo sapiens. The following page contains interesting information on the relation of 2HCK with [Src Tyrosine Kinase]. Full crystallographic information is available from OCA.

Reference

Crystal structure of the Src family tyrosine kinase Hck., Sicheri F, Moarefi I, Kuriyan J, Nature. 1997 Feb 13;385(6617):602-9. PMID:9024658 Page seeded by OCA on Sun May 4 06:07:31 2008

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