2hd5

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2hd5.gif|left|200px]]
[[Image:2hd5.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2hd5 |SIZE=350|CAPTION= <scene name='initialview01'>2hd5</scene>, resolution 1.850&Aring;
+
The line below this paragraph, containing "STRUCTURE_2hd5", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= USP2, UBP41 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2hd5| PDB=2hd5 | SCENE= }}
-
|RELATEDENTRY=[[1nb8|1NB8]], [[1nbf|1NBF]], [[2ayn|2AYN]], [[2ayo|2AYO]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hd5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hd5 OCA], [http://www.ebi.ac.uk/pdbsum/2hd5 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hd5 RCSB]</span>
+
-
}}
+
'''USP2 in complex with ubiquitin'''
'''USP2 in complex with ubiquitin'''
Line 29: Line 26:
[[Category: Kroemer, M.]]
[[Category: Kroemer, M.]]
[[Category: Renatus, M.]]
[[Category: Renatus, M.]]
-
[[Category: cysteine protease]]
+
[[Category: Cysteine protease]]
-
[[Category: deubiquitinating protease]]
+
[[Category: Deubiquitinating protease]]
-
[[Category: substrate enzyme complex]]
+
[[Category: Substrate enzyme complex]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:08:28 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:42 2008''
+

Revision as of 03:08, 4 May 2008

Image:2hd5.gif

Template:STRUCTURE 2hd5

USP2 in complex with ubiquitin


Overview

Deubiquitinating proteases reverse protein ubiquitination and rescue their target proteins from destruction by the proteasome. USP2, a cysteine protease and a member of the ubiquitin specific protease family, is overexpressed in prostate cancer and stabilizes fatty acid synthase, which has been associated with the malignancy of some aggressive prostate cancers. Here, we report the structure of the human USP2 catalytic domain in complex with ubiquitin. Ubiquitin uses two major sites for the interaction with the protease. Both sites are required simultaneously, as shown by USP2 inhibition assays with peptides and ubiquitin mutants. In addition, a layer of ordered water molecules mediates key interactions between ubiquitin and USP2. As several of those molecules are found at identical positions in the previously solved USP7/ubiquitin-aldehyde complex structure, we suggest a general mechanism of water-mediated ubiquitin recognition by USPs.

About this Structure

2HD5 is a Protein complex structure of sequences from Bos taurus and Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural basis of ubiquitin recognition by the deubiquitinating protease USP2., Renatus M, Parrado SG, D'Arcy A, Eidhoff U, Gerhartz B, Hassiepen U, Pierrat B, Riedl R, Vinzenz D, Worpenberg S, Kroemer M, Structure. 2006 Aug;14(8):1293-302. PMID:16905103 Page seeded by OCA on Sun May 4 06:08:28 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hd5"
Personal tools