2hdl

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[[Image:2hdl.jpg|left|200px]]
[[Image:2hdl.jpg|left|200px]]
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{{Structure
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|PDB= 2hdl |SIZE=350|CAPTION= <scene name='initialview01'>2hdl</scene>
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The line below this paragraph, containing "STRUCTURE_2hdl", creates the "Structure Box" on the page.
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|SITE=
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|GENE= CXCL14, NJAC, SCYB14 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2hdl| PDB=2hdl | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hdl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hdl OCA], [http://www.ebi.ac.uk/pdbsum/2hdl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hdl RCSB]</span>
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'''Solution structure of Brak/CXCL14'''
'''Solution structure of Brak/CXCL14'''
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[[Category: Thorpe, J A.]]
[[Category: Thorpe, J A.]]
[[Category: Volkman, B F.]]
[[Category: Volkman, B F.]]
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[[Category: brak]]
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[[Category: Brak]]
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[[Category: chemokine]]
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[[Category: Chemokine]]
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[[Category: cxcl14]]
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[[Category: Cxcl14]]
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[[Category: nmr]]
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[[Category: Nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:09:23 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:28:57 2008''
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Revision as of 03:09, 4 May 2008

Image:2hdl.jpg

Template:STRUCTURE 2hdl

Solution structure of Brak/CXCL14


Overview

The chemokine CXCL14/BRAK participates in immune surveillance by recruiting dendritic cells. CXCL14 gene expression is altered in a number of cancers, but protein expression levels have not been investigated. Here we report that CXCL14 protein can be expressed in primary epithelial cells; however, in several immortalized and cancer cell lines this protein is targeted for polyubiquitylation and proteasomal degradation. We determined the NMR structure of CXCL14 to identify motifs controlling its expression. CXCL14 adopts the canonical chemokine tertiary fold but contains a unique five amino acid insertion (41VSRYR45) relative to other CXC chemokines. Deletion or substitution of key residues within this insertion prevented proteasomal degradation. Furthermore, we defined a 15 amino acid fragment of CXCL14 that is sufficient to induce proteasomal degradation. This study elucidates a post-translational mechanism for the loss of CXCL14 in cancer and a novel mode of chemokine regulation.

About this Structure

2HDL is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural determinants involved in the regulation of CXCL14/BRAK expression by the 26 S proteasome., Peterson FC, Thorpe JA, Harder AG, Volkman BF, Schwarze SR, J Mol Biol. 2006 Nov 3;363(4):813-22. Epub 2006 Aug 26. PMID:16987528 Page seeded by OCA on Sun May 4 06:09:23 2008

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