2hha

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[[Image:2hha.gif|left|200px]]
[[Image:2hha.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hha |SIZE=350|CAPTION= <scene name='initialview01'>2hha</scene>, resolution 2.350&Aring;
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The line below this paragraph, containing "STRUCTURE_2hha", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=3TP:(2S,3S)-3-{3-[4-(METHYLSULFONYL)PHENYL]-1,2,4-OXADIAZOL-5-YL}-1-OXO-1-PYRROLIDIN-1-YLBUTAN-2-AMINE'>3TP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_IV Dipeptidyl-peptidase IV], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.5 3.4.14.5] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= DPP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_2hha| PDB=2hha | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hha FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hha OCA], [http://www.ebi.ac.uk/pdbsum/2hha PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hha RCSB]</span>
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}}
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'''The structure of DPP4 in complex with an oxadiazole inhibitor'''
'''The structure of DPP4 in complex with an oxadiazole inhibitor'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Scapin, G.]]
[[Category: Scapin, G.]]
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[[Category: alpha/beta]]
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[[Category: Alpha/beta]]
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[[Category: beta-propeller]]
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[[Category: Beta-propeller]]
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[[Category: dimer]]
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[[Category: Dimer]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:17:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:30:22 2008''
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Revision as of 03:17, 4 May 2008

Image:2hha.gif

Template:STRUCTURE 2hha

The structure of DPP4 in complex with an oxadiazole inhibitor


Overview

A novel series of oxadiazole based amides have been shown to be potent DPP-4 inhibitors. The optimized compound 43 exhibited excellent selectivity over a variety of DPP-4 homologs.

About this Structure

2HHA is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors., Xu J, Wei L, Mathvink RJ, Edmondson SD, Eiermann GJ, He H, Leone JF, Leiting B, Lyons KA, Marsilio F, Patel RA, Patel SB, Petrov A, Scapin G, Wu JK, Thornberry NA, Weber AE, Bioorg Med Chem Lett. 2006 Oct 15;16(20):5373-7. Epub 2006 Aug 17. PMID:16919457 Page seeded by OCA on Sun May 4 06:17:32 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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