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2pbh
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(New page: 200px<br /> <applet load="2pbh" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pbh, resolution 3.3Å" /> '''CRYSTAL STRUCTURE OF...)
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Revision as of 21:15, 12 November 2007
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CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN B AT 3.3 ANGSTROM RESOLUTION
Overview
A wild-type human procathepsin B was expressed, crystallized in two, crystal forms and its crystal structure determined at 3.2 and 3.3, Angstroms resolution. The structure reveals that the propeptide folds on, the cathepsin B surface, shielding the enzyme active site from exposure to, solvent. The structure of the enzymatically active domains is virtually, identical to that of the native enzyme [Musil et al. (1991) EMBO J. 10, 2321-2330]: the main difference is that the occluding loop residues are, lifted above the body of the mature enzyme, supporting the propeptide, structure.
About this Structure
2PBH is a Single protein structure of sequence from Homo sapiens. Active as Cathepsin B, with EC number 3.4.22.1 Full crystallographic information is available from OCA.
Reference
Crystal structures of human procathepsin B at 3.2 and 3.3 Angstroms resolution reveal an interaction motif between a papain-like cysteine protease and its propeptide., Turk D, Podobnik M, Kuhelj R, Dolinar M, Turk V, FEBS Lett. 1996 Apr 22;384(3):211-4. PMID:8617355
Page seeded by OCA on Mon Nov 12 23:22:12 2007
