2hio

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[[Image:2hio.gif|left|200px]]
[[Image:2hio.gif|left|200px]]
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{{Structure
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{{STRUCTURE_2hio| PDB=2hio | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hio FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hio OCA], [http://www.ebi.ac.uk/pdbsum/2hio PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hio RCSB]</span>
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'''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN'''
'''HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN'''
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[[Category: Arents, G.]]
[[Category: Arents, G.]]
[[Category: Moudrianakis, E N.]]
[[Category: Moudrianakis, E N.]]
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[[Category: chromosomal protein]]
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[[Category: Chromosomal protein]]
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[[Category: histone]]
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[[Category: Histone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:20:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:00 2008''
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Revision as of 03:20, 4 May 2008

Image:2hio.gif

Template:STRUCTURE 2hio

HISTONE OCTAMER (CHICKEN), CHROMOSOMAL PROTEIN


Overview

The structure of the octameric histone core of the nucleosome has been determined by x-ray crystallography to a resolution of 3.1 A. The histone octamer is a tripartite assembly in which a centrally located (H3-H4)2 tetramer is flanked by two H2A-H2B dimers. It has a complex outer surface; depending on the perspective, the structure appears as a wedge or as a flat disk. The disk represents the planar projection of a left-handed proteinaceous superhelix with approximately 28 A pitch. The diameter of the particle is 65 A and the length is 60 A at its maximum and approximately 10 A at its minimum extension; these dimensions are in agreement with those reported earlier by Klug et al. [Klug, A., Rhodes, D., Smith, J., Finch, J. T. & Thomas, J. O. (1980) Nature (London) 287, 509-516]. The folded histone chains are elongated rather than globular and are assembled in a characteristic "handshake" motif. The individual polypeptides share a common central structural element of the helix-loop-helix type, which we name the histone fold.

About this Structure

2HIO is a Protein complex structure of sequences from Gallus gallus. Full crystallographic information is available from OCA.

Reference

The nucleosomal core histone octamer at 3.1 A resolution: a tripartite protein assembly and a left-handed superhelix., Arents G, Burlingame RW, Wang BC, Love WE, Moudrianakis EN, Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10148-52. PMID:1946434 Page seeded by OCA on Sun May 4 06:20:32 2008

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