2hiu
From Proteopedia
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[[Image:2hiu.gif|left|200px]] | [[Image:2hiu.gif|left|200px]] | ||
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'''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES''' | '''NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HIU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry | + | 2HIU is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1hiu 1hiu]. The following page contains interesting information on the relation of 2HIU with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb14_1.html Insulin]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HIU OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Hua, Q X.]] | [[Category: Hua, Q X.]] | ||
[[Category: Weiss, M A.]] | [[Category: Weiss, M A.]] | ||
| - | [[Category: | + | [[Category: Glucose metabolism]] |
| - | [[Category: | + | [[Category: Hormone]] |
| - | [[Category: | + | [[Category: Insulin]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:20:47 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:20, 4 May 2008
NMR STRUCTURE OF HUMAN INSULIN IN 20% ACETIC ACID, ZINC-FREE, 10 STRUCTURES
Overview
We have determined the structure of a metastable disulphide isomer of human insulin. Although not observed for proinsulin folding or insulin-chain recombination, the isomer retains ordered secondary structure and a compact hydrophobic core. Comparison with native insulin reveals a global rearrangement in the orientation of A- and B-chains. One face of the protein's surface is nevertheless in common between native and non-native structures. This face contains receptor-binding determinants, rationalizing the partial biological activity of the isomer. Structures of native and non-native disulphide isomers also define alternative three-dimensional templates. Threading of insulin-like sequences provide an experimental realization of the inverse protein-folding problem.
About this Structure
2HIU is a Protein complex structure of sequences from Homo sapiens. This structure supersedes the now removed PDB entry 1hiu. The following page contains interesting information on the relation of 2HIU with [Insulin]. Full crystallographic information is available from OCA.
Reference
Structure of a protein in a kinetic trap., Hua QX, Gozani SN, Chance RE, Hoffmann JA, Frank BH, Weiss MA, Nat Struct Biol. 1995 Feb;2(2):129-38. PMID:7749917 Page seeded by OCA on Sun May 4 06:20:47 2008
