2hje

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[[Image:2hje.gif|left|200px]]
[[Image:2hje.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hje |SIZE=350|CAPTION= <scene name='initialview01'>2hje</scene>, resolution 1.70&Aring;
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The line below this paragraph, containing "STRUCTURE_2hje", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= luxQ ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=669 Vibrio harveyi])
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-->
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|DOMAIN=
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{{STRUCTURE_2hje| PDB=2hje | SCENE= }}
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|RELATEDENTRY=[[2hj9|2HJ9]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hje FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hje OCA], [http://www.ebi.ac.uk/pdbsum/2hje PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hje RCSB]</span>
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}}
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'''Crystal structure of Vibrio harveyi LuxQ periplasmic domain'''
'''Crystal structure of Vibrio harveyi LuxQ periplasmic domain'''
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[[Category: Kelly, R C.]]
[[Category: Kelly, R C.]]
[[Category: Neiditch, M B.]]
[[Category: Neiditch, M B.]]
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[[Category: autoinducer-2 (ai-2)]]
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[[Category: Histidine sensor kinase]]
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[[Category: histidine sensor kinase]]
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[[Category: Quorum sensing]]
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[[Category: per/arnt/simple-minded (pas) fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:21:48 2008''
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[[Category: quorum sensing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:17 2008''
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Revision as of 03:21, 4 May 2008

Image:2hje.gif

Template:STRUCTURE 2hje

Crystal structure of Vibrio harveyi LuxQ periplasmic domain


Overview

Bacteria sense their environment using receptors of the histidine sensor kinase family, but how kinase activity is regulated by ligand binding is not well understood. Autoinducer-2 (AI-2), a secreted signaling molecule originally identified in studies of the marine bacterium Vibrio harveyi, regulates quorum-sensing responses and allows communication between different bacterial species. AI-2 signal transduction in V. harveyi requires the integral membrane receptor LuxPQ, comprised of periplasmic binding protein (LuxP) and histidine sensor kinase (LuxQ) subunits. Combined X-ray crystallographic and functional studies show that AI-2 binding causes a major conformational change within LuxP, which in turn stabilizes a quaternary arrangement in which two LuxPQ monomers are asymmetrically associated. We propose that formation of this asymmetric quaternary structure is responsible for repressing the kinase activity of both LuxQ subunits and triggering the transition of V. harveyi into quorum-sensing mode.

About this Structure

2HJE is a Single protein structure of sequence from Vibrio harveyi. Full crystallographic information is available from OCA.

Reference

Ligand-induced asymmetry in histidine sensor kinase complex regulates quorum sensing., Neiditch MB, Federle MJ, Pompeani AJ, Kelly RC, Swem DL, Jeffrey PD, Bassler BL, Hughson FM, Cell. 2006 Sep 22;126(6):1095-108. PMID:16990134 Page seeded by OCA on Sun May 4 06:21:48 2008

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