2hkk

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[[Image:2hkk.jpg|left|200px]]
[[Image:2hkk.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2hkk |SIZE=350|CAPTION= <scene name='initialview01'>2hkk</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2hkk", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ALE:L-EPINEPHRINE'>ALE</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2hkk| PDB=2hkk | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hkk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hkk OCA], [http://www.ebi.ac.uk/pdbsum/2hkk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hkk RCSB]</span>
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}}
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'''Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms'''
'''Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms'''
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[[Category: Temperini, C.]]
[[Category: Temperini, C.]]
[[Category: Vullo, D.]]
[[Category: Vullo, D.]]
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[[Category: activator]]
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[[Category: Activator]]
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[[Category: carbonic anhydrase]]
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[[Category: Carbonic anhydrase]]
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[[Category: crystal structure]]
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[[Category: Crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:24:05 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:31:38 2008''
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Revision as of 03:24, 4 May 2008

Image:2hkk.jpg

Template:STRUCTURE 2hkk

Carbonic anhydrase activators: Solution and X-ray crystallography for the interaction of andrenaline with various carbonic anhydrase isoforms


Overview

The activation of the metalloenzyme carbonic anhydrase (CA, EC 4.2.1.1) with L-adrenaline and histamine has been investigated by kinetic and X-ray crystallographic studies. L-Adrenaline behaves as a potent activator of isozyme CA I (activation constant of 90 nM), being a much weaker activator of isozyme CA II (activation constant of 96 microM). Isoforms CA IV, VA, VII, and XIV were activated by L-adrenaline with K(A)s in the range of 36-63 microM. The X-ray crystal structure of the CA II-L-adrenaline adduct revealed that the activator plugs the entrance of the active site cavity, obstructing it almost completely.

About this Structure

2HKK is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Carbonic anhydrase activators: L-Adrenaline plugs the active site entrance of isozyme II, activating better isoforms I, IV, VA, VII, and XIV., Temperini C, Innocenti A, Scozzafava A, Mastrolorenzo A, Supuran CT, Bioorg Med Chem Lett. 2007 Feb 1;17(3):628-35. Epub 2006 Nov 15. PMID:17127057 Page seeded by OCA on Sun May 4 06:24:05 2008

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