2hmh

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[[Image:2hmh.gif|left|200px]]
[[Image:2hmh.gif|left|200px]]
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{{Structure
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|PDB= 2hmh |SIZE=350|CAPTION= <scene name='initialview01'>2hmh</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2hmh", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CAS:S-(DIMETHYLARSENIC)CYSTEINE'>CAS</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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|GENE= Socs3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 Mus musculus])
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{{STRUCTURE_2hmh| PDB=2hmh | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hmh OCA], [http://www.ebi.ac.uk/pdbsum/2hmh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hmh RCSB]</span>
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'''Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.'''
'''Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.'''
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[[Category: Hubbard, S R.]]
[[Category: Hubbard, S R.]]
[[Category: Wu, J.]]
[[Category: Wu, J.]]
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[[Category: gp130]]
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[[Category: Gp130]]
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[[Category: peptide complex]]
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[[Category: Peptide complex]]
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[[Category: ptyr]]
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[[Category: Ptyr]]
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[[Category: socs3]]
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[[Category: Socs3]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:27:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:22 2008''
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Revision as of 03:27, 4 May 2008

Image:2hmh.gif

Template:STRUCTURE 2hmh

Crystal structure of SOCS3 in complex with gp130(pTyr757) phosphopeptide.


Overview

Suppressor of cytokine signaling (SOCS) proteins are indispensable negative regulators of cytokine-stimulated Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling pathways. SOCS proteins (SOCS1-7 and CIS) consist of a variable N-terminal region, a central Src homology-2 (SH2) domain, and a C-terminal SOCS box. The N-terminal region in SOCS1 and SOCS3 includes the so-called kinase inhibitory region that has been shown to inhibit the catalytic activity of JAK2. Here, we present a crystal structure at 2.0 A resolution of the N-terminally extended SH2 domain of SOCS3 in complex with its phosphopeptide target on the cytokine receptor gp130. The structure reveals that major insertions in the EF and BG loops of the SOCS3 SH2 domain are responsible for binding to gp130 with high affinity and specificity. In addition, the structure provides insights into the possible mechanisms by which SOCS3 and SOCS1 inhibit JAK2 kinase activity.

About this Structure

2HMH is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.

Reference

Structural basis for phosphotyrosine recognition by suppressor of cytokine signaling-3., Bergamin E, Wu J, Hubbard SR, Structure. 2006 Aug;14(8):1285-92. PMID:16905102 Page seeded by OCA on Sun May 4 06:27:36 2008

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