2hmt

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[[Image:2hmt.jpg|left|200px]]
[[Image:2hmt.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2hmt |SIZE=350|CAPTION= <scene name='initialview01'>2hmt</scene>, resolution 2.200&Aring;
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The line below this paragraph, containing "STRUCTURE_2hmt", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=NAI:1,4-DIHYDRONICOTINAMIDE+ADENINE+DINUCLEOTIDE'>NAI</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= yuaA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
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|DOMAIN=
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{{STRUCTURE_2hmt| PDB=2hmt | SCENE= }}
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|RELATEDENTRY=[[1lsu|1LSU]], [[1lss|1LSS]], [[1lnq|1LNQ]], [[2hms|2HMS]], [[2hmu|2HMU]], [[2hmv|2HMV]], [[2hmw|2HMW]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hmt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hmt OCA], [http://www.ebi.ac.uk/pdbsum/2hmt PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hmt RCSB]</span>
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'''Diamond-shaped octameric ring structure of an RCK domain with NADH bound'''
'''Diamond-shaped octameric ring structure of an RCK domain with NADH bound'''
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[[Category: Albright, R A.]]
[[Category: Albright, R A.]]
[[Category: Morais-Cabral, J H.]]
[[Category: Morais-Cabral, J H.]]
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[[Category: ion transporter]]
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[[Category: Ion transporter]]
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[[Category: ktn]]
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[[Category: Ktn]]
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[[Category: ktr]]
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[[Category: Ktr]]
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[[Category: ktra]]
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[[Category: Ktra]]
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[[Category: ktrab]]
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[[Category: Ktrab]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: rck]]
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[[Category: Rck]]
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[[Category: symporter]]
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[[Category: Symporter]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:28:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:32 2008''
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Revision as of 03:28, 4 May 2008

Image:2hmt.jpg

Template:STRUCTURE 2hmt

Diamond-shaped octameric ring structure of an RCK domain with NADH bound


Overview

The KtrAB ion transporter is a complex of the KtrB membrane protein and KtrA, an RCK domain. RCK domains regulate eukaryotic and prokaryotic membrane proteins involved in K(+) transport. Conflicting functional models have proposed two different oligomeric arrangements for RCK domains, tetramer versus octamer. Our results for the KtrAB RCK domain clearly show an octamer in solution and in the crystal. We determined the structure of this protein in three different octameric ring conformations that resemble the RCK-domain octamer observed in the MthK potassium channel but show striking differences in size and symmetry. We present experimental evidence for the association between one RCK octameric ring and two KtrB membrane proteins. These results provide insights into the quaternary organization of the KtrAB transporter and its mechanism of activation and show that the RCK-domain octameric ring model is generally applicable to other ion-transport systems.

About this Structure

2HMT is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The RCK domain of the KtrAB K+ transporter: multiple conformations of an octameric ring., Albright RA, Ibar JL, Kim CU, Gruner SM, Morais-Cabral JH, Cell. 2006 Sep 22;126(6):1147-59. PMID:16990138 Page seeded by OCA on Sun May 4 06:28:20 2008

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OCA

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