2hnh

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[[Image:2hnh.gif|left|200px]]
[[Image:2hnh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hnh |SIZE=350|CAPTION= <scene name='initialview01'>2hnh</scene>, resolution 2.30&Aring;
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The line below this paragraph, containing "STRUCTURE_2hnh", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= dnaE, polC ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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-->
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|DOMAIN=
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{{STRUCTURE_2hnh| PDB=2hnh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hnh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hnh OCA], [http://www.ebi.ac.uk/pdbsum/2hnh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hnh RCSB]</span>
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}}
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'''Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III'''
'''Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III'''
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[[Category: Lee, S.]]
[[Category: Lee, S.]]
[[Category: Meindert, M H.]]
[[Category: Meindert, M H.]]
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[[Category: dna polymerase iii]]
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[[Category: Dna polymerase iii]]
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[[Category: dna replication]]
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[[Category: Dna replication]]
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[[Category: nucleotidyltransferase]]
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[[Category: Nucleotidyltransferase]]
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[[Category: php]]
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[[Category: Php]]
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[[Category: pol beta]]
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[[Category: Pol beta]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:22 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:45 2008''
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Revision as of 03:29, 4 May 2008

Image:2hnh.gif

Template:STRUCTURE 2hnh

Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III


Overview

Bacterial replicative DNA polymerases such as Polymerase III (Pol III) share no sequence similarity with other polymerases. The crystal structure, determined at 2.3 A resolution, of a large fragment of Pol III (residues 1-917), reveals a unique chain fold with localized similarity in the catalytic domain to DNA polymerase beta and related nucleotidyltransferases. The structure of Pol III is strikingly different from those of members of the canonical DNA polymerase families, which include eukaryotic replicative polymerases, suggesting that the DNA replication machinery in bacteria arose independently. A structural element near the active site in Pol III that is not present in nucleotidyltransferases but which resembles an element at the active sites of some canonical DNA polymerases suggests that, at a more distant level, all DNA polymerases may share a common ancestor. The structure also suggests a model for interaction of Pol III with the sliding clamp and DNA.

About this Structure

2HNH is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III., Lamers MH, Georgescu RE, Lee SG, O'Donnell M, Kuriyan J, Cell. 2006 Sep 8;126(5):881-92. PMID:16959568 Page seeded by OCA on Sun May 4 06:29:22 2008

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