2hnk

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2hnk.jpg|left|200px]]
[[Image:2hnk.jpg|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2hnk |SIZE=350|CAPTION= <scene name='initialview01'>2hnk</scene>, resolution 2.300&Aring;
+
The line below this paragraph, containing "STRUCTURE_2hnk", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE=
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2hnk| PDB=2hnk | SCENE= }}
-
|RELATEDENTRY=
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hnk OCA], [http://www.ebi.ac.uk/pdbsum/2hnk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hnk RCSB]</span>
+
-
}}
+
'''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''
'''Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans'''
Line 28: Line 25:
[[Category: Hou, X.]]
[[Category: Hou, X.]]
[[Category: Wei, Z.]]
[[Category: Wei, Z.]]
-
[[Category: modified rossman fold]]
+
[[Category: Modified rossman fold]]
-
[[Category: transferase]]
+
[[Category: Transferase]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:34 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:44 2008''
+

Revision as of 03:29, 4 May 2008

Image:2hnk.jpg

Template:STRUCTURE 2hnk

Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans


Overview

The S-adenosylmethionine (SAM)-dependent O-methyltransferase from Leptospira interrogans (LiOMT) expressed by gene LA0415 belongs to the Methyltransf_3 family (Pfam PF01596). In this family all of the five bacterial homologues with known function are reported as SAM-dependent O-methylstransferases involved in antibiotic production. The crystal structure of LiOMT in complex with S-adenosylhomocysteine reported here is the first bacterial protein structure in this family. The LiOMT structure shows a conserved SAM-binding region and a probable metal-dependent catalytic site. The molecules of LiOMT generate homodimers by N-terminal swapping, which assists the pre-organization of the substrate-binding site. Based on the sequence and structural analysis, it is implied by the catalytic and substrate-binding site that the substrate of LiOMT is a phenolic derivative, which probably has a large ring-shaped moiety.

About this Structure

2HNK is a Single protein structure of sequence from Leptospira interrogans. Full crystallographic information is available from OCA.

Reference

Crystal structure of SAM-dependent O-methyltransferase from pathogenic bacterium Leptospira interrogans., Hou X, Wang Y, Zhou Z, Bao S, Lin Y, Gong W, J Struct Biol. 2007 Sep;159(3):523-8. Epub 2007 Apr 30. PMID:17561415 Page seeded by OCA on Sun May 4 06:29:34 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2hnk"
Personal tools