2hnx

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[[Image:2hnx.gif|left|200px]]
[[Image:2hnx.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hnx |SIZE=350|CAPTION= <scene name='initialview01'>2hnx</scene>, resolution 1.50&Aring;
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The line below this paragraph, containing "STRUCTURE_2hnx", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= FABP4 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2hnx| PDB=2hnx | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hnx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hnx OCA], [http://www.ebi.ac.uk/pdbsum/2hnx PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hnx RCSB]</span>
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}}
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'''Crystal Structure of aP2'''
'''Crystal Structure of aP2'''
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[[Category: Qiu, X.]]
[[Category: Qiu, X.]]
[[Category: Tardie, M.]]
[[Category: Tardie, M.]]
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[[Category: fatty acid binding protein]]
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[[Category: Fatty acid binding protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:29:59 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:32:52 2008''
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Revision as of 03:30, 4 May 2008

Image:2hnx.gif

Template:STRUCTURE 2hnx

Crystal Structure of aP2


Overview

Human adipocyte lipid-binding protein (aP2) belongs to a family of intracellular lipid-binding proteins involved in the transport and storage of lipids. Here, the crystal structure of human aP2 with a bound palmitate is described at 1.5 A resolution. Unlike the known crystal structure of murine aP2 in complex with palmitate, this structure shows that the fatty acid is in a folded conformation and that the loop containing Phe57 acts as a lid to regulate ligand binding by excluding solvent exposure to the central binding cavity.

About this Structure

2HNX is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Expression, purification, crystallization and structure of human adipocyte lipid-binding protein (aP2)., Marr E, Tardie M, Carty M, Brown Phillips T, Wang IK, Soeller W, Qiu X, Karam G, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1058-60. Epub 2006 Oct 25. PMID:17077479 Page seeded by OCA on Sun May 4 06:29:59 2008

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OCA

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