2hr9

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[[Image:2hr9.gif|left|200px]]
[[Image:2hr9.gif|left|200px]]
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{{Structure
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The line below this paragraph, containing "STRUCTURE_2hr9", creates the "Structure Box" on the page.
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|GENE= TPT1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2hr9| PDB=2hr9 | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hr9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hr9 OCA], [http://www.ebi.ac.uk/pdbsum/2hr9 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hr9 RCSB]</span>
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'''Solution structure of human translationally controlled tumor protein'''
'''Solution structure of human translationally controlled tumor protein'''
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==About this Structure==
==About this Structure==
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2HR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry 1Y41. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
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2HR9 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1y41 1y41]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HR9 OCA].
==Reference==
==Reference==
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[[Category: Wang, J.]]
[[Category: Wang, J.]]
[[Category: Yao, H.]]
[[Category: Yao, H.]]
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[[Category: apoptosis]]
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[[Category: Apoptosis]]
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[[Category: metal binding protein]]
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[[Category: Metal binding protein]]
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[[Category: tumor protein]]
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[[Category: Tumor protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:37:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:34:23 2008''
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Revision as of 03:37, 4 May 2008

Image:2hr9.gif

Template:STRUCTURE 2hr9

Solution structure of human translationally controlled tumor protein


Overview

Human translationally controlled tumor protein (TCTP) is a growth-related, calcium-binding protein. We determined the solution structure and backbone dynamics of human TCTP, and identified the calcium-binding site of human TCTP using multi-dimensional NMR spectroscopy. The overall structure of human TCTP has a rather rigid well-folded core and a very flexible long loop connected by a short two-strand beta-sheet, which shows a conserved fold in the TCTP family. The C-terminal portions of loop L(alpha3beta8) and strand beta9 and the N-terminal region of strand beta8 may form a calcium-binding site in the human TCTP structure, which is largely conserved in the sequence alignment of TCTPs. The K(d) value for the calcium binding is 0.022-0.025 M indicating a very weak calcium-binding site.

About this Structure

2HR9 is a Single protein structure of sequence from Homo sapiens. This structure supersedes the now removed PDB entry 1y41. Full crystallographic information is available from OCA.

Reference

Solution structure and mapping of a very weak calcium-binding site of human translationally controlled tumor protein by NMR., Feng Y, Liu D, Yao H, Wang J, Arch Biochem Biophys. 2007 Nov 1;467(1):48-57. Epub 2007 Aug 30. PMID:17897616 Page seeded by OCA on Sun May 4 06:37:02 2008

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