2hrt
From Proteopedia
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'''Asymmetric structure of trimeric AcrB from Escherichia coli''' | '''Asymmetric structure of trimeric AcrB from Escherichia coli''' | ||
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[[Category: Seeger, M A.]] | [[Category: Seeger, M A.]] | ||
[[Category: Verrey, F.]] | [[Category: Verrey, F.]] | ||
| - | [[Category: | + | [[Category: Acra]] |
| - | [[Category: | + | [[Category: Acrb]] |
| - | [[Category: | + | [[Category: Antibiotic resistance]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Multidrug efflux pump]] |
| - | [[Category: | + | [[Category: Proton-coupled exchanger]] |
| - | [[Category: | + | [[Category: Rnd]] |
| - | [[Category: | + | [[Category: Tolc]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:38:15 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:38, 4 May 2008
Asymmetric structure of trimeric AcrB from Escherichia coli
Overview
The AcrA/AcrB/TolC complex spans the inner and outer membranes of Escherichia coli and serves as its major drug-resistance pump. Driven by the proton motive force, it mediates the efflux of bile salts, detergents, organic solvents, and many structurally unrelated antibiotics. Here, we report a crystallographic structure of trimeric AcrB determined at 2.9 and 3.0 angstrom resolution in space groups that allow asymmetry of the monomers. This structure reveals three different monomer conformations representing consecutive states in a transport cycle. The structural data imply an alternating access mechanism and a novel peristaltic mode of drug transport by this type of transporter.
About this Structure
2HRT is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.
Reference
Structural asymmetry of AcrB trimer suggests a peristaltic pump mechanism., Seeger MA, Schiefner A, Eicher T, Verrey F, Diederichs K, Pos KM, Science. 2006 Sep 1;313(5791):1295-8. PMID:16946072 Page seeded by OCA on Sun May 4 06:38:15 2008
