2hrv

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[[Image:2hrv.jpg|left|200px]]
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{{Structure
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|PDB= 2hrv |SIZE=350|CAPTION= <scene name='initialview01'>2hrv</scene>, resolution 1.95&Aring;
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The line below this paragraph, containing "STRUCTURE_2hrv", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Picornain_2A Picornain 2A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.22.29 3.4.22.29] </span>
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{{STRUCTURE_2hrv| PDB=2hrv | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hrv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hrv OCA], [http://www.ebi.ac.uk/pdbsum/2hrv PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hrv RCSB]</span>
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'''2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2'''
'''2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2'''
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[[Category: Petersen, J F.W.]]
[[Category: Petersen, J F.W.]]
[[Category: Skern, T.]]
[[Category: Skern, T.]]
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[[Category: hydrolase (cysteine proteinase)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:38:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:34:34 2008''
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Revision as of 03:38, 4 May 2008

Image:2hrv.jpg

Template:STRUCTURE 2hrv

2A CYSTEINE PROTEINASE FROM HUMAN RHINOVIRUS 2


Overview

The crystal structure of the 2A proteinase from human rhinovirus serotype 2 (HRV2-2A(pro)) has been solved to 1.95 A resolution. The structure has an unusual, although chymotrypsin-related, fold comprising a unique four-stranded beta sheet as the N-terminal domain and a six-stranded beta barrel as the C-terminal domain. A tightly bound zinc ion, essential for the stability of HRV2-2A(pro), is tetrahedrally coordinated by three cysteine sulfurs and one histidine nitrogen. The active site consists of a catalytic triad formed by His18, Asp35 and Cys106. Asp35 is additionally involved in an extensive hydrogen-bonding network. Modelling studies reveal a substrate-induced fit that explains the specificity of the subsites S4, S2, S1 and S1'. The structure of HRV2-2A(pro) suggests the mechanism of the cis cleavage and its release from the polyprotein.

About this Structure

2HRV is a Single protein structure of sequence from Human rhinovirus 2. Full crystallographic information is available from OCA.

Reference

The structure of the 2A proteinase from a common cold virus: a proteinase responsible for the shut-off of host-cell protein synthesis., Petersen JF, Cherney MM, Liebig HD, Skern T, Kuechler E, James MN, EMBO J. 1999 Oct 15;18(20):5463-75. PMID:10523291 Page seeded by OCA on Sun May 4 06:38:20 2008

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