2hur

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[[Image:2hur.gif|left|200px]]
[[Image:2hur.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2hur |SIZE=350|CAPTION= <scene name='initialview01'>2hur</scene>, resolution 1.62&Aring;
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The line below this paragraph, containing "STRUCTURE_2hur", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-diphosphate_kinase Nucleoside-diphosphate kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.4.6 2.7.4.6] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ndk ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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|DOMAIN=
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{{STRUCTURE_2hur| PDB=2hur | SCENE= }}
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|RELATEDENTRY=[[2nck|2NCK]], [[1npk|1NPK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hur FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hur OCA], [http://www.ebi.ac.uk/pdbsum/2hur PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hur RCSB]</span>
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}}
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'''Escherichia coli nucleoside diphosphate kinase'''
'''Escherichia coli nucleoside diphosphate kinase'''
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[[Category: Lascu, I.]]
[[Category: Lascu, I.]]
[[Category: Moynie, L.]]
[[Category: Moynie, L.]]
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[[Category: type ii tetramer]]
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[[Category: Type ii tetramer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:44:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:35:42 2008''
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Revision as of 03:44, 4 May 2008

Image:2hur.gif

Template:STRUCTURE 2hur

Escherichia coli nucleoside diphosphate kinase


Overview

Nucleoside diphosphate kinase (NDPK) catalyzes the transfer of gamma-phosphate from nucleoside triphosphates to nucleoside diphosphates. The subunit folding and the dimeric basic structural unit are remarkably the same for available structures but, depending on species, dimers self-associate to form hexamers or tetramers. The crystal structure of the Escherichia coli NDPK reveals a new tetrameric quaternary structure for this protein family. The two tetramers differ by the relative orientation of interacting dimers, which face either the convex or the concave side of their central sheet as in either Myxococcus xanthus (type I) or E. coli (type II), respectively. In the type II tetramer, the subunits interact by a new interface harboring a zone called the Kpn loop as in hexamers, but by the opposite face of this loop. The evolutionary conservation of the interface residues indicates that this new quaternary structure seems to be the most frequent assembly mode in bacterial tetrameric NDP kinases.

About this Structure

2HUR is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

The structure of the Escherichia coli nucleoside diphosphate kinase reveals a new quaternary architecture for this enzyme family., Moynie L, Giraud MF, Georgescauld F, Lascu I, Dautant A, Proteins. 2007 May 15;67(3):755-65. PMID:17330300 Page seeded by OCA on Sun May 4 06:44:09 2008

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