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2hva
From Proteopedia
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[[Image:2hva.gif|left|200px]] | [[Image:2hva.gif|left|200px]] | ||
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'''Solution Structure of the haem-binding protein p22HBP''' | '''Solution Structure of the haem-binding protein p22HBP''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2HVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry | + | 2HVA is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2hc6 2hc6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVA OCA]. |
==Reference== | ==Reference== | ||
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[[Category: Mackay, J P.]] | [[Category: Mackay, J P.]] | ||
[[Category: Westman, B J.]] | [[Category: Westman, B J.]] | ||
| - | [[Category: | + | [[Category: Beta-beta-alpha-beta-beta repeat]] |
| - | [[Category: | + | [[Category: Haem-binding protein]] |
| - | [[Category: | + | [[Category: Hydrophobic-ligand binding domain]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:45:16 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:45, 4 May 2008
Solution Structure of the haem-binding protein p22HBP
Overview
The 22 kDa haem-binding protein, p22HBP, is highly expressed in erythropoietic tissues and binds to a range of metallo- and non-metalloporphyrin molecules with similar affinities, suggesting a role in haem regulation or synthesis. We have determined the three-dimensional solution structure of p22HBP and mapped the porphyrin-binding site, which comprises a number of loops and a alpha-helix all located on a single face of the molecule. The structure of p22HBP is related to the bacterial multi-drug resistance protein BmrR, and is the first protein with this fold to be identified in eukaryotes. Strikingly, the porphyrin-binding site in p22HBP is located in a similar position to the drug-binding site of BmrR. These similarities suggest that the broad ligand specificity observed for both BmrR and p22HBP may result from a conserved ligand interaction mechanism. Taken together, these data suggest that the both the fold and its associated function, that of binding to a broad range of small hydrophobic molecules, are ancient, and have been adapted throughout evolution for a variety of purposes.
About this Structure
2HVA is a Single protein structure of sequence from Mus musculus. This structure supersedes the now removed PDB entry 2hc6. Full crystallographic information is available from OCA.
Reference
A novel haem-binding interface in the 22 kDa haem-binding protein p22HBP., Gell DA, Westman BJ, Gorman D, Liew C, Welch JJ, Weiss MJ, Mackay JP, J Mol Biol. 2006 Sep 15;362(2):287-97. Epub 2006 Aug 14. PMID:16905148 Page seeded by OCA on Sun May 4 06:45:16 2008
