2hxy
From Proteopedia
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[[Image:2hxy.gif|left|200px]] | [[Image:2hxy.gif|left|200px]] | ||
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'''Crystal structure of human apo-eIF4AIII''' | '''Crystal structure of human apo-eIF4AIII''' | ||
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[[Category: Andersen, G R.]] | [[Category: Andersen, G R.]] | ||
[[Category: Johansen, J S.]] | [[Category: Johansen, J S.]] | ||
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| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:51:01 2008'' | |
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Revision as of 03:51, 4 May 2008
Crystal structure of human apo-eIF4AIII
Overview
In higher eukaryotes, a multiprotein exon junction complex is deposited on spliced messenger RNAs. The complex is organized around a stable core, which serves as a binding platform for numerous factors that influence messenger RNA function. Here, we present the crystal structure of a tetrameric exon junction core complex containing the DEAD-box adenosine triphosphatase (ATPase) eukaryotic initiation factor 4AIII (eIF4AIII) bound to an ATP analog, MAGOH, Y14, a fragment of MLN51, and a polyuracil mRNA mimic. eIF4AIII interacts with the phosphate-ribose backbone of six consecutive nucleotides and prevents part of the bound RNA from being double stranded. The MAGOH and Y14 subunits lock eIF4AIII in a prehydrolysis state, and activation of the ATPase probably requires only modest conformational changes in eIF4AIII motif I.
About this Structure
2HXY is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNA., Andersen CB, Ballut L, Johansen JS, Chamieh H, Nielsen KH, Oliveira CL, Pedersen JS, Seraphin B, Le Hir H, Andersen GR, Science. 2006 Sep 29;313(5795):1968-72. Epub 2006 Aug 24. PMID:16931718 Page seeded by OCA on Sun May 4 06:51:01 2008
