We apologize for Proteopedia being slow to respond. For the past two years, a new implementation of Proteopedia has been being built. Soon, it will replace this 18-year old system. All existing content will be moved to the new system at a date that will be announced here.

2pzy

From Proteopedia

(Difference between revisions)
Jump to: navigation, search

OCA (Talk | contribs)
(New page: 200px<br /> <applet load="2pzy" size="450" color="white" frame="true" align="right" spinBox="true" caption="2pzy, resolution 2.900&Aring;" /> '''Structure of MK2 C...)
Next diff →

Revision as of 21:22, 12 November 2007

Image:2pzy.gif

2pzy, resolution 2.900Å

Drag the structure with the mouse to rotate

Structure of MK2 Complexed with Compound 76

Overview

The discovery of a series of potent, carboline-based MK2 inhibitors is, described. These compounds inhibit MK2 with IC(50)s as low as 10nM, as, measured in a DELFIA assay. An X-ray crystal structure reveals that they, bind in a region near the p-loop and the hinge region of MK2a.

About this Structure

2PZY is a Single protein structure of sequence from Homo sapiens with B18 and STU as ligands. Active as Non-specific serine/threonine protein kinase, with EC number 2.7.11.1 Full crystallographic information is available from OCA.

Reference

The discovery of carboline analogs as potent MAPKAP-K2 inhibitors., Wu JP, Wang J, Abeywardane A, Andersen D, Emmanuel M, Gautschi E, Goldberg DR, Kashem MA, Lukas S, Mao W, Martin L, Morwick T, Moss N, Pargellis C, Patel UR, Patnaude L, Peet GW, Skow D, Snow RJ, Ward Y, Werneburg B, White A, Bioorg Med Chem Lett. 2007 Aug 15;17(16):4664-9. Epub 2007 Jun 7. PMID:17576063

Page seeded by OCA on Mon Nov 12 23:28:31 2007

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2pzy"
Personal tools