2hy9
From Proteopedia
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[[Image:2hy9.gif|left|200px]] | [[Image:2hy9.gif|left|200px]] | ||
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| - | + | {{STRUCTURE_2hy9| PDB=2hy9 | SCENE= }} | |
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'''solution structure of the human telomeric quadruplex''' | '''solution structure of the human telomeric quadruplex''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | + | Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HY9 OCA]. | |
==Reference== | ==Reference== | ||
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17395643 17395643] | Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17395643 17395643] | ||
| - | [[Category: Protein complex]] | ||
[[Category: Dai, J.]] | [[Category: Dai, J.]] | ||
[[Category: Hurley, L.]] | [[Category: Hurley, L.]] | ||
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[[Category: Punchihewa, C.]] | [[Category: Punchihewa, C.]] | ||
[[Category: Yang, D.]] | [[Category: Yang, D.]] | ||
| - | [[Category: | + | [[Category: G-quadruplex]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:51:43 2008'' | |
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Revision as of 03:51, 4 May 2008
solution structure of the human telomeric quadruplex
Overview
We report the NMR solution structure of the intramolecular G-quadruplex formed in human telomeric DNA in K(+). The hybrid-type telomeric G-quadruplex consists of three G-tetrads linked with mixed parallel-antiparallel G-strands, with the bottom two G-tetrads having the same G-arrangement (anti:anti:syn:anti) and the top G-tetrad having the reversed G-arrangement (syn:syn:anti:syn). The three TTA loop segments adopt different conformations, with the first TTA assuming a double-chain-reversal loop conformation, and the second and third TTA assuming lateral loop conformations. The NMR structure is very well defined, including the three TTA loops and the two flanking sequences at 5'- and 3'-ends. Our study indicates that the three loop regions interact with the core G-tetrads in a specific way that defines and stabilizes the unique human telomeric G-quadruplex structure in K(+). Significantly, a novel adenine triple platform is formed with three naturally occurring adenine residues, A21, A3 and A9, capping the top tetrad of the hybrid-type telomeric G-quadruplex. This adenine triple is likely to play an important role in the formation of a stable human telomeric G-quadruplex structure in K(+). The unique human telomeric G-quadruplex structure formed in K(+) suggests that it can be specifically targeted for anticancer drug design.
About this Structure
Full crystallographic information is available from OCA.
Reference
Structure of the intramolecular human telomeric G-quadruplex in potassium solution: a novel adenine triple formation., Dai J, Punchihewa C, Ambrus A, Chen D, Jones RA, Yang D, Nucleic Acids Res. 2007;35(7):2440-50. Epub 2007 Mar 29. PMID:17395643 Page seeded by OCA on Sun May 4 06:51:43 2008
