2hyd

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[[Image:2hyd.gif|left|200px]]
[[Image:2hyd.gif|left|200px]]
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{{Structure
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|PDB= 2hyd |SIZE=350|CAPTION= <scene name='initialview01'>2hyd</scene>, resolution 3.0&Aring;
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The line below this paragraph, containing "STRUCTURE_2hyd", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=ADP:ADENOSINE-5&#39;-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>
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|GENE= SAV1866 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 Staphylococcus aureus])
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{{STRUCTURE_2hyd| PDB=2hyd | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2hyd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hyd OCA], [http://www.ebi.ac.uk/pdbsum/2hyd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2hyd RCSB]</span>
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'''Multidrug ABC transporter SAV1866'''
'''Multidrug ABC transporter SAV1866'''
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[[Category: Dawson, R J.P.]]
[[Category: Dawson, R J.P.]]
[[Category: Locher, K P.]]
[[Category: Locher, K P.]]
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[[Category: transport protein]]
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[[Category: Transport protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 06:51:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:37:10 2008''
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Revision as of 03:51, 4 May 2008

Image:2hyd.gif


PDB ID 2hyd

Drag the structure with the mouse to rotate
2hyd, resolution 3.00Å ()
Ligands: ,
Gene: SAV1866 (Staphylococcus aureus)
Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Multidrug ABC transporter SAV1866


Overview

Multidrug transporters of the ABC family facilitate the export of diverse cytotoxic drugs across cell membranes. This is clinically relevant, as tumour cells may become resistant to agents used in chemotherapy. To understand the molecular basis of this process, we have determined the 3.0 A crystal structure of a bacterial ABC transporter (Sav1866) from Staphylococcus aureus. The homodimeric protein consists of 12 transmembrane helices in an arrangement that is consistent with cross-linking studies and electron microscopic imaging of the human multidrug resistance protein MDR1, but critically different from that reported for the bacterial lipid flippase MsbA. The observed, outward-facing conformation reflects the ATP-bound state, with the two nucleotide-binding domains in close contact and the two transmembrane domains forming a central cavity--presumably the drug translocation pathway--that is shielded from the inner leaflet of the lipid bilayer and from the cytoplasm, but exposed to the outer leaflet and the extracellular space.

About this Structure

2HYD is a Single protein structure of sequence from Staphylococcus aureus. Full crystallographic information is available from OCA.

Reference

Structure of a bacterial multidrug ABC transporter., Dawson RJ, Locher KP, Nature. 2006 Sep 14;443(7108):180-5. Epub 2006 Aug 30. PMID:16943773 Page seeded by OCA on Sun May 4 06:51:49 2008

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