2q1l

From Proteopedia

---

Revision as of 21:22, 12 November 2007

proteopedia linkproteopedia link

spinqualitylabelsall models 2q1l, resolution 2.050Å Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image

Design and Synthesis of Pyrrole-based, Hepatoselective HMG-CoA Reductase Inhibitors

Contents 1 Overview 2 Disease 3 About this Structure 4 Reference

Overview

This manuscript describes the design and synthesis of a series of, pyrrole-based inhibitors of HMG-CoA reductase for the treatment of, hypercholesterolemia. Analogs were optimized using structure-based design, and physical property considerations resulting in the identification of, 44, a hepatoselective HMG-CoA reductase inhibitor with excellent acute and, chronic efficacy in a pre-clinical animal models.

Disease

Known disease associated with this structure: Statins, attenuated cholesterol lowering by OMIM:[142910]

About this Structure

2Q1L is a Single protein structure of sequence from Homo sapiens with 882 as ligand. Active as Hydroxymethylglutaryl-CoA reductase (NADPH), with EC number 1.1.1.34 Full crystallographic information is available from OCA.

Reference

Design and synthesis of hepatoselective, pyrrole-based HMG-CoA reductase inhibitors., Pfefferkorn JA, Song Y, Sun KL, Miller SR, Trivedi BK, Choi C, Sorenson RJ, Bratton LD, Unangst PC, Larsen SD, Poel TJ, Cheng XM, Lee C, Erasga N, Auerbach B, Askew V, Dillon L, Hanselman JC, Lin Z, Lu G, Robertson A, Olsen K, Mertz T, Sekerke C, Pavlovsky A, Harris MS, Bainbridge G, Caspers N, Chen H, Eberstadt M, Bioorg Med Chem Lett. 2007 Jun 6;. PMID:17574412

Page seeded by OCA on Mon Nov 12 23:28:53 2007