2i28
From Proteopedia
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[[Image:2i28.jpg|left|200px]] | [[Image:2i28.jpg|left|200px]] | ||
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| - | + | {{STRUCTURE_2i28| PDB=2i28 | SCENE= }} | |
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'''Solution Structure of alpha-Conotoxin BuIA''' | '''Solution Structure of alpha-Conotoxin BuIA''' | ||
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==About this Structure== | ==About this Structure== | ||
| - | 2I28 is a [[Single protein]] structure | + | 2I28 is a [[Single protein]] structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I28 OCA]. |
==Reference== | ==Reference== | ||
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[[Category: McIntosh, J M.]] | [[Category: McIntosh, J M.]] | ||
[[Category: Olivera, B M.]] | [[Category: Olivera, B M.]] | ||
| - | [[Category: | + | [[Category: Alpha-helix]] |
| - | [[Category: | + | [[Category: Beta-turn]] |
| - | [[Category: | + | [[Category: C-terminal amidation]] |
| - | [[Category: | + | [[Category: Two disulfide bond]] |
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| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 03:59, 4 May 2008
Solution Structure of alpha-Conotoxin BuIA
Overview
We have determined a high-resolution three-dimensional structure of alpha-conotoxin BuIA, a 13-residue peptide toxin isolated from Conus bullatus. Despite its unusual 4/4 disulfide bond layout alpha-conotoxin BuIA exhibits strong antagonistic activity at alpha6/alpha3beta2beta3, alpha3beta2, and alpha3beta4 nAChR subtypes like some alpha4/7 conotoxins. alpha-Conotoxin BuIA lacks the C-terminal beta-turn present within the second disulfide loop of alpha4/7 conotoxins, having only a "pseudo omega-shaped" molecular topology. Nevertheless, it contains a functionally critical two-turn helix motif, a feature ubiquitously found in alpha4/7 conotoxins. Such an aspect seems mainly responsible for similarities in the receptor recognition profile of alpha-conotoxin BuIA to alpha4/7 conotoxins. Structural comparison of alpha-conotoxin BuIA with alpha4/7 conotoxins and alpha4/3 conotoxin ImI suggests that presence of the second helical turn portion of the two-turn helix motif in alpha4/7 and alpha4/4 conotoxins may be important for binding to the alpha3 and/or alpha6 subunit of nAChR.
About this Structure
2I28 is a Single protein structure. Full crystallographic information is available from OCA.
Reference
NMR structure determination of alpha-conotoxin BuIA, a novel neuronal nicotinic acetylcholine receptor antagonist with an unusual 4/4 disulfide scaffold., Chi SW, Kim DH, Olivera BM, McIntosh JM, Han KH, Biochem Biophys Res Commun. 2006 Nov 3;349(4):1228-34. Epub 2006 Sep 7. PMID:16979596 Page seeded by OCA on Sun May 4 06:59:25 2008
