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2i2r
From Proteopedia
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[[Image:2i2r.jpg|left|200px]] | [[Image:2i2r.jpg|left|200px]] | ||
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'''Crystal structure of the KChIP1/Kv4.3 T1 complex''' | '''Crystal structure of the KChIP1/Kv4.3 T1 complex''' | ||
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[[Category: Jr., D L.Minor.]] | [[Category: Jr., D L.Minor.]] | ||
[[Category: Pioletti, M.]] | [[Category: Pioletti, M.]] | ||
| - | [[Category: | + | [[Category: Calcium binding protein]] |
| - | [[Category: | + | [[Category: Complex]] |
| - | [[Category: | + | [[Category: Ef-hand protein]] |
| - | [[Category: | + | [[Category: Ncs protein]] |
| - | [[Category: | + | [[Category: Potassium channel]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:00:09 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:00, 4 May 2008
Crystal structure of the KChIP1/Kv4.3 T1 complex
Overview
Brain I(A) and cardiac I(to) currents arise from complexes containing Kv4 voltage-gated potassium channels and cytoplasmic calcium-sensor proteins (KChIPs). Here, we present X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites. Site 1 comprises interactions between a unique Kv4 channel N-terminal hydrophobic segment and a hydrophobic pocket formed by displacement of the KChIP H10 helix. Site 2 comprises interactions between a T1 assembly domain loop and the KChIP H2 helix. Functional and biochemical studies indicate that site 1 influences channel trafficking, whereas site 2 affects channel gating, and that calcium binding is intimately linked to KChIP folding and complex formation. Together, the data resolve how Kv4 channels and KChIPs interact and provide a framework for understanding how KChIPs modulate Kv4 function.
About this Structure
2I2R is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer., Pioletti M, Findeisen F, Hura GL, Minor DL Jr, Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22. PMID:17057713 Page seeded by OCA on Sun May 4 07:00:09 2008
