2i2r

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[[Image:2i2r.jpg|left|200px]]
[[Image:2i2r.jpg|left|200px]]
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{{Structure
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|PDB= 2i2r |SIZE=350|CAPTION= <scene name='initialview01'>2i2r</scene>, resolution 3.35&Aring;
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The line below this paragraph, containing "STRUCTURE_2i2r", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= Kcnd3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]), KCNIP1, KCHIP1, VABP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2i2r| PDB=2i2r | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i2r OCA], [http://www.ebi.ac.uk/pdbsum/2i2r PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i2r RCSB]</span>
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}}
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'''Crystal structure of the KChIP1/Kv4.3 T1 complex'''
'''Crystal structure of the KChIP1/Kv4.3 T1 complex'''
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[[Category: Jr., D L.Minor.]]
[[Category: Jr., D L.Minor.]]
[[Category: Pioletti, M.]]
[[Category: Pioletti, M.]]
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[[Category: calcium binding protein]]
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[[Category: Calcium binding protein]]
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[[Category: complex]]
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[[Category: Complex]]
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[[Category: ef-hand protein]]
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[[Category: Ef-hand protein]]
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[[Category: ncs protein]]
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[[Category: Ncs protein]]
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[[Category: potassium channel]]
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[[Category: Potassium channel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:00:09 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:38:54 2008''
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Revision as of 04:00, 4 May 2008

Image:2i2r.jpg

Template:STRUCTURE 2i2r

Crystal structure of the KChIP1/Kv4.3 T1 complex


Overview

Brain I(A) and cardiac I(to) currents arise from complexes containing Kv4 voltage-gated potassium channels and cytoplasmic calcium-sensor proteins (KChIPs). Here, we present X-ray crystallographic and small-angle X-ray scattering data that show that the KChIP1-Kv4.3 N-terminal cytoplasmic domain complex is a cross-shaped octamer bearing two principal interaction sites. Site 1 comprises interactions between a unique Kv4 channel N-terminal hydrophobic segment and a hydrophobic pocket formed by displacement of the KChIP H10 helix. Site 2 comprises interactions between a T1 assembly domain loop and the KChIP H2 helix. Functional and biochemical studies indicate that site 1 influences channel trafficking, whereas site 2 affects channel gating, and that calcium binding is intimately linked to KChIP folding and complex formation. Together, the data resolve how Kv4 channels and KChIPs interact and provide a framework for understanding how KChIPs modulate Kv4 function.

About this Structure

2I2R is a Protein complex structure of sequences from Homo sapiens and Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Three-dimensional structure of the KChIP1-Kv4.3 T1 complex reveals a cross-shaped octamer., Pioletti M, Findeisen F, Hura GL, Minor DL Jr, Nat Struct Mol Biol. 2006 Nov;13(11):987-95. Epub 2006 Oct 22. PMID:17057713 Page seeded by OCA on Sun May 4 07:00:09 2008

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