2i3v

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2i3v.gif|left|200px]]
[[Image:2i3v.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2i3v |SIZE=350|CAPTION= <scene name='initialview01'>2i3v</scene>, resolution 2.40&Aring;
+
The line below this paragraph, containing "STRUCTURE_2i3v", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=GLU:GLUTAMIC+ACID'>GLU</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= Gria2, Glur2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2i3v| PDB=2i3v | SCENE= }}
-
|RELATEDENTRY=[[1ftj|1FTJ]], [[2i3w|2I3W]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i3v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i3v OCA], [http://www.ebi.ac.uk/pdbsum/2i3v PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i3v RCSB]</span>
+
-
}}
+
'''Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant'''
'''Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant'''
Line 29: Line 26:
[[Category: Gouaux, E.]]
[[Category: Gouaux, E.]]
[[Category: Jasti, J.]]
[[Category: Jasti, J.]]
-
[[Category: ionotropic glutamate receptor ligand binding core s1s2 g725c mutant]]
+
[[Category: Ionotropic glutamate receptor ligand binding core s1s2 g725c mutant]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:02:13 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:39:18 2008''
+

Revision as of 04:02, 4 May 2008

Template:STRUCTURE 2i3v

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor: Structure of G725C mutant


Overview

The canonical conformational states occupied by most ligand-gated ion channels, and many cell-surface receptors, are the resting, activated, and desensitized states. While the resting and activated states of multiple receptors are well characterized, elaboration of the structural properties of the desensitized state, a state that is by definition inactive, has proven difficult. Here we use electrical, chemical, and crystallographic experiments on the AMPA-sensitive GluR2 receptor, defining the conformational rearrangements of the agonist binding cores that occur upon desensitization of this ligand-gated ion channel. These studies demonstrate that desensitization involves the rupture of an extensive interface between domain 1 of 2-fold related glutamate-binding core subunits, compensating for the ca. 21 degrees of domain closure induced by glutamate binding. The rupture of the domain 1 interface allows the ion channel to close and thereby provides a simple explanation to the long-standing question of how agonist binding is decoupled from ion channel gating upon receptor desensitization.

About this Structure

2I3V is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Measurement of conformational changes accompanying desensitization in an ionotropic glutamate receptor., Armstrong N, Jasti J, Beich-Frandsen M, Gouaux E, Cell. 2006 Oct 6;127(1):85-97. PMID:17018279 Page seeded by OCA on Sun May 4 07:02:13 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Personal tools