2i5d

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[[Image:2i5d.gif|left|200px]]
[[Image:2i5d.gif|left|200px]]
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{{Structure
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|PDB= 2i5d |SIZE=350|CAPTION= <scene name='initialview01'>2i5d</scene>, resolution 1.630&Aring;
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The line below this paragraph, containing "STRUCTURE_2i5d", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Nucleoside-triphosphate_diphosphatase Nucleoside-triphosphate diphosphatase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.6.1.19 3.6.1.19] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= ITPA, C20orf37 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2i5d| PDB=2i5d | SCENE= }}
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|RELATEDENTRY=[[2car|2CAR]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i5d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i5d OCA], [http://www.ebi.ac.uk/pdbsum/2i5d PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i5d RCSB]</span>
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}}
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'''Crystal Structure of Human Inosine Triphosphate Pyrophosphatase'''
'''Crystal Structure of Human Inosine Triphosphate Pyrophosphatase'''
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[[Category: Pavlov, Y I.]]
[[Category: Pavlov, Y I.]]
[[Category: Porta, J C.]]
[[Category: Porta, J C.]]
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[[Category: monomeric protein]]
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[[Category: Monomeric protein]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:05:31 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:39:54 2008''
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Revision as of 04:05, 4 May 2008

Image:2i5d.gif

Template:STRUCTURE 2i5d

Crystal Structure of Human Inosine Triphosphate Pyrophosphatase


Overview

The structure of human inosine triphosphate pyrophosphohydrolase (ITPA) has been determined using diffraction data to 1.6 A resolution. ITPA contributes to the accurate replication of DNA by cleansing cellular dNTP pools of mutagenic nucleotide purine analogs such as dITP or dXTP. A similar high-resolution unpublished structure has been deposited in the Protein Data Bank from a monoclinic and pseudo-merohedrally twinned crystal. Here, cocrystallization of ITPA with a molar ratio of XTP appears to have improved the crystals by eliminating twinning and resulted in an orthorhombic space group. However, there was no evidence for bound XTP in the structure. Comparison with substrate-bound NTPase from a thermophilic organism predicts the movement of residues within helix alpha1, the loop before alpha6 and helix alpha7 to cap off the active site when substrate is bound.

About this Structure

2I5D is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the orthorhombic form of human inosine triphosphate pyrophosphatase., Porta J, Kolar C, Kozmin SG, Pavlov YI, Borgstahl GE, Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Nov 1;62(Pt, 11):1076-81. Epub 2006 Oct 25. PMID:17077483 Page seeded by OCA on Sun May 4 07:05:31 2008

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