2i6q

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:2i6q.gif|left|200px]]
[[Image:2i6q.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 2i6q |SIZE=350|CAPTION= <scene name='initialview01'>2i6q</scene>, resolution 2.100&Aring;
+
The line below this paragraph, containing "STRUCTURE_2i6q", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Classical-complement-pathway_C3/C5_convertase Classical-complement-pathway C3/C5 convertase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.43 3.4.21.43] </span>
+
or leave the SCENE parameter empty for the default display.
-
|GENE= C2a ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_2i6q| PDB=2i6q | SCENE= }}
-
|RELATEDENTRY=[[2i6s|2I6S]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6q OCA], [http://www.ebi.ac.uk/pdbsum/2i6q PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i6q RCSB]</span>
+
-
}}
+
'''Complement component C2a'''
'''Complement component C2a'''
Line 36: Line 33:
[[Category: Schouten, A.]]
[[Category: Schouten, A.]]
[[Category: Vandeputte, D A.A.]]
[[Category: Vandeputte, D A.A.]]
-
[[Category: serine protease domain]]
+
[[Category: Serine protease domain]]
-
[[Category: von willebrand factor-a domain]]
+
[[Category: Von willebrand factor-a domain]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:08:41 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:29 2008''
+

Revision as of 04:08, 4 May 2008

Image:2i6q.gif

Template:STRUCTURE 2i6q

Complement component C2a


Overview

C2a provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation. We determined two crystal structures of full-length C2a, with and without a pseudo ligand bound. Both structures reveal a near-active conformation of the catalytic center of the serine protease domains, while the von Willebrand factor A-type domains display an intermediate activation state of helix alpha7 with an open, activated metal-ion-dependent adhesion site. The open adhesion site likely serves to enhance the affinity for the ligand C4b, similar to "inside-out" signaling in integrins. Surprisingly, the N-terminal residues of C2a are buried in a crevice near helix alpha7, indicative of a structural switch between C2 and C2a. Extended loops on the protease domain possibly envelop the protruding anaphylatoxin domain of the substrate C3. Together with a putative substrate-induced completion of the oxyanion hole, this may contribute to the high substrate specificity of the convertases.

About this Structure

2I6Q is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of complement component C2A: implications for convertase formation and substrate binding., Milder FJ, Raaijmakers HC, Vandeputte MD, Schouten A, Huizinga EG, Romijn RA, Hemrika W, Roos A, Daha MR, Gros P, Structure. 2006 Oct;14(10):1587-97. PMID:17027507 Page seeded by OCA on Sun May 4 07:08:41 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2i6q"
Personal tools