2i6t

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[[Image:2i6t.jpg|left|200px]]
[[Image:2i6t.jpg|left|200px]]
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{{Structure
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|PDB= 2i6t |SIZE=350|CAPTION= <scene name='initialview01'>2i6t</scene>, resolution 2.10&Aring;
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The line below this paragraph, containing "STRUCTURE_2i6t", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|GENE= UEVLD ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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|DOMAIN=
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{{STRUCTURE_2i6t| PDB=2i6t | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6t OCA], [http://www.ebi.ac.uk/pdbsum/2i6t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i6t RCSB]</span>
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'''Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A'''
'''Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A'''
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[[Category: Weigelt, J.]]
[[Category: Weigelt, J.]]
[[Category: Xue, S.]]
[[Category: Xue, S.]]
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[[Category: l-lactate dehydrogenase]]
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[[Category: L-lactate dehydrogenase]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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[[Category: ubiquitin-protein ligase]]
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[[Category: Ubiquitin-protein ligase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:09:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:33 2008''
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Revision as of 04:09, 4 May 2008

Image:2i6t.jpg

Template:STRUCTURE 2i6t

Orthorhombic Structure of the LDH domain of Human Ubiquitin-conjugating Enzyme E2-like Isoform A


Overview

Recent studies have shown that ubiquitination is an essential factor in endosomal sorting and virus assembly. The human TSG101 gene has been demonstrated to belong to a group of genes coding for apparently inactive E2 ubiquitin-conjugating enzymes, which exert regulatory effects on E2 activity in cellular ubiquitination processes. In this study, a novel human cDNA (UEV3) encoding a putative protein of 379 amino acids was isolated from a human placenta library that may represent a partial paralogue of human TSG101. The predicted protein contains an N-terminal domain homologous to the catalytic domain of ubiquitin-conjugating enzymes (Ubc), which is fused to a sequence showing significant homology to members of the lactate dehydrogenase protein family. The UEV3 gene is located on chromosome 11 closely adjacent to TSG101 and LDH-C. Northern blot and UEV3-specific reverse transcription/polymerase chain reaction (RT/PCR) analyses of various colon carcinoma cell lines as well as both normal and tumor samples from colon revealed an expression of the UEV3 cDNA in all tested samples.

About this Structure

2I6T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification and characterization of UEV3, a human cDNA with similarities to inactive E2 ubiquitin-conjugating enzymes., Kloor M, Bork P, Duwe A, Klaes R, von Knebel Doeberitz M, Ridder R, Biochim Biophys Acta. 2002 Dec 12;1579(2-3):219-24. PMID:12427560 Page seeded by OCA on Sun May 4 07:09:02 2008

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