2i6z

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[[Image:2i6z.jpg|left|200px]]
[[Image:2i6z.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2i6z |SIZE=350|CAPTION= <scene name='initialview01'>2i6z</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_2i6z", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Cpt+Binding+Site+For+Residue+A+300'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+500'>AC2</scene> and <scene name='pdbsite=AC3:Dms+Binding+Site+For+Residue+A+400'>AC3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CPT:CIS-PLATINUM-(NH3)2'>CPT</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_2i6z| PDB=2i6z | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i6z OCA], [http://www.ebi.ac.uk/pdbsum/2i6z PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2i6z RCSB]</span>
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}}
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'''X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'''
'''X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme'''
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[[Category: Messori, L.]]
[[Category: Messori, L.]]
[[Category: Temperini, C.]]
[[Category: Temperini, C.]]
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[[Category: anticancer drug]]
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[[Category: Anticancer drug]]
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[[Category: cisplatin-lysozyme adduct]]
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[[Category: Cisplatin-lysozyme adduct]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:09:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:40:34 2008''
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Revision as of 04:09, 4 May 2008

Image:2i6z.jpg

Template:STRUCTURE 2i6z

X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme


Overview

The interactions of cisplatin and its analogues, transplatin, carboplatin and oxaliplatin, with hen egg white lysozyme were analysed through ESI mass spectrometry, and the resulting metallodrug-protein adducts identified; the X-ray crystal structure of the cisplatin lysozyme derivative, solved at 1.9 A resolution, reveals selective platination of imidazole Nepsilon of His15.

About this Structure

2I6Z is a Single protein structure of sequence from Gallus gallus. Full crystallographic information is available from OCA.

Reference

ESI mass spectrometry and X-ray diffraction studies of adducts between anticancer platinum drugs and hen egg white lysozyme., Casini A, Mastrobuoni G, Temperini C, Gabbiani C, Francese S, Moneti G, Supuran CT, Scozzafava A, Messori L, Chem Commun (Camb). 2007 Jan 14;(2):156-8. Epub 2006 Oct 26. PMID:17180231 Page seeded by OCA on Sun May 4 07:09:28 2008

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OCA

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