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2icw

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[[Image:2icw.gif|left|200px]]
[[Image:2icw.gif|left|200px]]
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{{Structure
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|PDB= 2icw |SIZE=350|CAPTION= <scene name='initialview01'>2icw</scene>, resolution 2.410&Aring;
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The line below this paragraph, containing "STRUCTURE_2icw", creates the "Structure Box" on the page.
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|SITE=
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|GENE= HLA-DRA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), HLA-DRB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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{{STRUCTURE_2icw| PDB=2icw | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2icw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2icw OCA], [http://www.ebi.ac.uk/pdbsum/2icw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2icw RCSB]</span>
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'''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''
'''Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule'''
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[[Category: Wang, L.]]
[[Category: Wang, L.]]
[[Category: Zhao, Y.]]
[[Category: Zhao, Y.]]
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[[Category: mhc]]
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[[Category: Mhc]]
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[[Category: protein-protein complex]]
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[[Category: Protein-protein complex]]
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[[Category: superantigen]]
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[[Category: Superantigen]]
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[[Category: tcr]]
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[[Category: Tcr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:20:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:42:33 2008''
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Revision as of 04:20, 4 May 2008

Image:2icw.gif

Template:STRUCTURE 2icw

Crystal structure of a complete ternary complex between TCR, superantigen, and peptide-MHC class II molecule


Overview

'Superantigens' (SAgs) trigger the massive activation of T cells by simultaneous interactions with MHC and TCR receptors, leading to human diseases. Here we present the first crystal structure, at 2.5-A resolution, of a complete ternary complex between a SAg and its two receptors, HLA-DR1/HA and TCR. The most striking finding is that the SAg Mycoplasma arthritidis mitogen, unlike others, has direct contacts not only with TCR Vbeta but with TCR Valpha.

About this Structure

2ICW is a Protein complex structure of sequences from Homo sapiens, Mus musculus and Mycoplasma arthritidis. Full crystallographic information is available from OCA.

Reference

Crystal structure of a complete ternary complex of TCR, superantigen and peptide-MHC., Wang L, Zhao Y, Li Z, Guo Y, Jones LL, Kranz DM, Mourad W, Li H, Nat Struct Mol Biol. 2007 Feb;14(2):169-71. Epub 2007 Jan 14. PMID:17220897 Page seeded by OCA on Sun May 4 07:20:38 2008

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