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2r6n

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(New page: 200px<br /> <applet load="2r6n" size="450" color="white" frame="true" align="right" spinBox="true" caption="2r6n, resolution 1.950&Aring;" /> '''Crystal structure ...)
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Revision as of 21:29, 12 November 2007

Image:2r6n.gif

2r6n, resolution 1.950Å

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Crystal structure of a pyrrolopyrimidine inhibitor in complex with human Cathepsin K

Contents

Overview

Pyrrolopyrimidine, a novel scaffold, allows to adjust interactions within, the S3 subsite of cathepsin K. The core intermediate 10 facilitated the P3, optimization and identified highly potent and selective cathepsin K, inhibitors 11-20.

Disease

Known disease associated with this structure: Pycnodysostosis OMIM:[601105]

About this Structure

2R6N is a Single protein structure of sequence from Homo sapiens with CKE as ligand. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.

Reference

Novel scaffold for cathepsin K inhibitors., Teno N, Miyake T, Ehara T, Irie O, Sakaki J, Ohmori O, Gunji H, Matsuura N, Masuya K, Hitomi Y, Nonomura K, Horiuchi M, Gohda K, Iwasaki A, Umemura I, Tada S, Kometani M, Iwasaki G, Cowan-Jacob SW, Missbach M, Lattmann R, Betschart C, Bioorg Med Chem Lett. 2007 Nov 15;17(22):6096-100. Epub 2007 Sep 15. PMID:17911019

Page seeded by OCA on Mon Nov 12 23:36:16 2007

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