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2ikq
From Proteopedia
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[[Image:2ikq.jpg|left|200px]] | [[Image:2ikq.jpg|left|200px]] | ||
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'''Crystal structure of mouse Sts-1 PGM domain in complex with phosphate''' | '''Crystal structure of mouse Sts-1 PGM domain in complex with phosphate''' | ||
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[[Category: Chen, Y.]] | [[Category: Chen, Y.]] | ||
[[Category: Nassar, N.]] | [[Category: Nassar, N.]] | ||
| - | [[Category: | + | [[Category: Acid phosphatase]] |
| - | [[Category: | + | [[Category: Immune system]] |
| - | [[Category: | + | [[Category: Pgm]] |
| - | [[Category: | + | [[Category: Phospho-histidine enzyme]] |
| - | [[Category: | + | [[Category: Signaling protein]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:36:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:36, 4 May 2008
Crystal structure of mouse Sts-1 PGM domain in complex with phosphate
Overview
Precise signaling by the T cell receptor (TCR) is crucial for a proper immune response. To ensure that T cells respond appropriately to antigenic stimuli, TCR signaling pathways are subject to multiple levels of regulation. Sts-1 negatively regulates signaling pathways downstream of the TCR by an unknown mechanism(s). Here, we demonstrate that Sts-1 is a phosphatase that can target the tyrosine kinase Zap-70 among other proteins. The X-ray structure of the Sts-1 C terminus reveals that it has homology to members of the phosphoglycerate mutase/acid phosphatase (PGM/AcP) family of enzymes, with residues known to be important for PGM/AcP catalytic activity conserved in nature and position in Sts-1. Point mutations that impair Sts-1 phosphatase activity in vitro also impair the ability of Sts-1 to regulate TCR signaling in T cells. These observations reveal a PGM/AcP-like enzyme activity involved in the control of antigen receptor signaling.
About this Structure
2IKQ is a Single protein structure of sequence from Mus musculus. Full crystallographic information is available from OCA.
Reference
A phosphatase activity of Sts-1 contributes to the suppression of TCR signaling., Mikhailik A, Ford B, Keller J, Chen Y, Nassar N, Carpino N, Mol Cell. 2007 Aug 3;27(3):486-97. PMID:17679096 Page seeded by OCA on Sun May 4 07:36:48 2008
