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2ipy

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[[Image:2ipy.gif|left|200px]]
[[Image:2ipy.gif|left|200px]]
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{{Structure
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|PDB= 2ipy |SIZE=350|CAPTION= <scene name='initialview01'>2ipy</scene>, resolution 2.80&Aring;
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The line below this paragraph, containing "STRUCTURE_2ipy", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=A:ADENOSINE-5&#39;-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Aconitate_hydratase Aconitate hydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.3 4.2.1.3] </span>
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{{STRUCTURE_2ipy| PDB=2ipy | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ipy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ipy OCA], [http://www.ebi.ac.uk/pdbsum/2ipy PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ipy RCSB]</span>
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'''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA'''
'''crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA'''
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[[Category: Volz, K.]]
[[Category: Volz, K.]]
[[Category: Walden, W E.]]
[[Category: Walden, W E.]]
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[[Category: protein-rna complex]]
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[[Category: Protein-rna complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:45:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:47:19 2008''
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Revision as of 04:45, 4 May 2008

Image:2ipy.gif

Template:STRUCTURE 2ipy

crystal structure of iron regulatory protein 1 in complex with ferritin H IRE-RNA


Overview

Iron regulatory protein 1 (IRP1) binds iron-responsive elements (IREs) in messenger RNAs (mRNAs), to repress translation or degradation, or binds an iron-sulfur cluster, to become a cytosolic aconitase enzyme. The 2.8 angstrom resolution crystal structure of the IRP1:ferritin H IRE complex shows an open protein conformation compared with that of cytosolic aconitase. The extended, L-shaped IRP1 molecule embraces the IRE stem-loop through interactions at two sites separated by approximately 30 angstroms, each involving about a dozen protein:RNA bonds. Extensive conformational changes related to binding the IRE or an iron-sulfur cluster explain the alternate functions of IRP1 as an mRNA regulator or enzyme.

About this Structure

2IPY is a Single protein structure of sequence from Oryctolagus cuniculus. The following page contains interesting information on the relation of 2IPY with [Aconitase and Iron Regulatory Protein 1]. Full crystallographic information is available from OCA.

Reference

Structure of dual function iron regulatory protein 1 complexed with ferritin IRE-RNA., Walden WE, Selezneva AI, Dupuy J, Volbeda A, Fontecilla-Camps JC, Theil EC, Volz K, Science. 2006 Dec 22;314(5807):1903-8. PMID:17185597 Page seeded by OCA on Sun May 4 07:45:41 2008

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