2isd

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[[Image:2isd.jpg|left|200px]]
[[Image:2isd.jpg|left|200px]]
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{{Structure
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|PDB= 2isd |SIZE=350|CAPTION= <scene name='initialview01'>2isd</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_2isd", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phosphoinositide_phospholipase_C Phosphoinositide phospholipase C], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.11 3.1.4.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= CDNA FRAGMENT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus])
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|DOMAIN=
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{{STRUCTURE_2isd| PDB=2isd | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2isd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2isd OCA], [http://www.ebi.ac.uk/pdbsum/2isd PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2isd RCSB]</span>
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}}
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'''PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT'''
'''PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT'''
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==About this Structure==
==About this Structure==
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2ISD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry 1ISD. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISD OCA].
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2ISD is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=1isd 1isd]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2ISD OCA].
==Reference==
==Reference==
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[[Category: Perisic, O.]]
[[Category: Perisic, O.]]
[[Category: Williams, R L.]]
[[Category: Williams, R L.]]
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[[Category: calcium-binding]]
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[[Category: Calcium-binding]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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[[Category: lipid degradation]]
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[[Category: Lipid degradation]]
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[[Category: phosphoinositide-specific]]
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[[Category: Phosphoinositide-specific]]
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[[Category: phospholipase c]]
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[[Category: Phospholipase c]]
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[[Category: phosphoric diester hydrolase]]
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[[Category: Phosphoric diester hydrolase]]
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[[Category: transducer]]
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[[Category: Transducer]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:48:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:47:50 2008''
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Revision as of 04:48, 4 May 2008

Image:2isd.jpg

Template:STRUCTURE 2isd

PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C-DELTA1 FROM RAT


Overview

Mammalian phosphoinositide-specific phospholipase C enzymes (PI-PLC) act as signal transducers that generate two second messengers, inositol-1,4,5-trisphosphate and diacylglycerol. The 2.4-A structure of phospholipase C delta 1 reveals a multidomain protein incorporating modules shared by many signalling proteins. The structure suggests a mechanism for membrane attachment and Ca2+-dependent hydrolysis of second-messenger precursors. The regulation and reversible membrane association of PI-PLC may serve as a model for understanding other multidomain enzymes involved in phospholipid signalling.

About this Structure

2ISD is a Single protein structure of sequence from Rattus norvegicus. This structure supersedes the now removed PDB entry 1isd. Full crystallographic information is available from OCA.

Reference

Crystal structure of a mammalian phosphoinositide-specific phospholipase C delta., Essen LO, Perisic O, Cheung R, Katan M, Williams RL, Nature. 1996 Apr 18;380(6575):595-602. PMID:8602259 Page seeded by OCA on Sun May 4 07:48:42 2008

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OCA

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