2ith

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[[Image:2ith.jpg|left|200px]]
[[Image:2ith.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 2ith |SIZE=350|CAPTION= <scene name='initialview01'>2ith</scene>
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The line below this paragraph, containing "STRUCTURE_2ith", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydrofolate_reductase Dihydrofolate reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.1.3 1.5.1.3] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= folA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=2246 Haloferax volcanii])
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-->
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|DOMAIN=
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{{STRUCTURE_2ith| PDB=2ith | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2ith FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2ith OCA], [http://www.ebi.ac.uk/pdbsum/2ith PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2ith RCSB]</span>
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}}
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'''NMR Structure of Haloferax volcanii DHFR'''
'''NMR Structure of Haloferax volcanii DHFR'''
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[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Binbuga, B.]]
[[Category: Binbuga, B.]]
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[[Category: dhfr]]
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[[Category: Dhfr]]
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[[Category: dihydrofolate reductase]]
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[[Category: Dihydrofolate reductase]]
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[[Category: halophilic archaea]]
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[[Category: Halophilic archaea]]
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[[Category: oxidoreductase]]
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[[Category: Oxidoreductase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:51:00 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:28 2008''
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Revision as of 04:51, 4 May 2008

Image:2ith.jpg

Template:STRUCTURE 2ith

NMR Structure of Haloferax volcanii DHFR


Overview

Proteins from halophiles have adapted to challenging environmental conditions and require salt for their structure and function. How halophilic proteins adapted to a hypersaline environment is still an intriguing question. It is important to mimic the physiological conditions of the archae extreme halophiles when characterizing their enzymes, including structural characterization. The NMR derived structure of Haloferax volcanii dihydrofolate reductase in 3.5 M NaCl is presented, and represents the first high salt structure calculated using NMR data. Structure calculations show that this protein has a solution structure which is similar to the previously determined crystal structure with a difference at the N terminus of beta3 and the type of beta-turn connection beta7 and beta8.

About this Structure

2ITH is a Single protein structure of sequence from Haloferax volcanii. Full crystallographic information is available from OCA.

Reference

Structure in an extreme environment: NMR at high salt., Binbuga B, Boroujerdi AF, Young JK, Protein Sci. 2007 Aug;16(8):1783-7. PMID:17656587 Page seeded by OCA on Sun May 4 07:51:00 2008

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