2iuh

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[[Image:2iuh.gif|left|200px]]
[[Image:2iuh.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2iuh |SIZE=350|CAPTION= <scene name='initialview01'>2iuh</scene>, resolution 2.00&Aring;
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The line below this paragraph, containing "STRUCTURE_2iuh", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene>
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|ACTIVITY=
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2iuh| PDB=2iuh | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iuh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iuh OCA], [http://www.ebi.ac.uk/pdbsum/2iuh PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iuh RCSB]</span>
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}}
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'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE'''
'''CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE'''
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[[Category: Schlessinger, J.]]
[[Category: Schlessinger, J.]]
[[Category: Shoelson, S E.]]
[[Category: Shoelson, S E.]]
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[[Category: disease mutation]]
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[[Category: Disease mutation]]
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[[Category: p85]]
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[[Category: P85]]
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[[Category: phosphorylation]]
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[[Category: Phosphorylation]]
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[[Category: pi3-kinase]]
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[[Category: Pi3-kinase]]
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[[Category: pi3k]]
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[[Category: Pi3k]]
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[[Category: polymorphism]]
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[[Category: Polymorphism]]
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[[Category: sh2]]
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[[Category: Sh2]]
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[[Category: sh2 domain]]
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[[Category: Sh2 domain]]
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[[Category: sh3 domain]]
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[[Category: Sh3 domain]]
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[[Category: transferase]]
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[[Category: Transferase]]
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[[Category: ubl conjugation]]
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[[Category: Ubl conjugation]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:53:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:47 2008''
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Revision as of 04:53, 4 May 2008

Image:2iuh.gif

Template:STRUCTURE 2iuh

CRYSTAL STRUCTURE OF THE PI3-KINASE P85 N-TERMINAL SH2 DOMAIN IN COMPLEX WITH C-KIT PHOSPHOTYROSYL PEPTIDE


Overview

Crystal structures of the amino-terminal SH2 domain of the p85alpha subunit of phosphatidylinositol (PI) 3-kinase, alone and in complex with phosphopeptides bearing pTyr-Met/Val-Xaa-Met motifs, show that phosphopeptides bind in the two-pronged manner seen in high-affinity Lck and Src SH2 complexes, with conserved interactions between the domain and the peptide segment from phosphotyrosine to Met+3. Peptide binding requires the rearrangement of a tyrosyl side chain in the BG loop to create the hydrophobic Met+3 binding pocket. The structures suggest a mechanism for the biological specificity exhibited by PI 3-kinase in its interactions with phosphoprotein partners.

About this Structure

2IUH is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of the PI 3-kinase p85 amino-terminal SH2 domain and its phosphopeptide complexes., Nolte RT, Eck MJ, Schlessinger J, Shoelson SE, Harrison SC, Nat Struct Biol. 1996 Apr;3(4):364-74. PMID:8599763 Page seeded by OCA on Sun May 4 07:53:50 2008

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