2iut

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[[Image:2iut.gif|left|200px]]
[[Image:2iut.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 2iut |SIZE=350|CAPTION= <scene name='initialview01'>2iut</scene>, resolution 2.25&Aring;
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The line below this paragraph, containing "STRUCTURE_2iut", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=AC1:Atg+Binding+Site+For+Chain+B'>AC1</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=ATG:PHOSPHOTHIOPHOSPHORIC+ACID-ADENYLATE+ESTER'>ATG</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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|DOMAIN=
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{{STRUCTURE_2iut| PDB=2iut | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2iut FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2iut OCA], [http://www.ebi.ac.uk/pdbsum/2iut PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2iut RCSB]</span>
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}}
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'''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC'''
'''P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC'''
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[[Category: Sherratt, D J.]]
[[Category: Sherratt, D J.]]
[[Category: Yates, J.]]
[[Category: Yates, J.]]
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[[Category: aaa atpase]]
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[[Category: Aaa atpase]]
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[[Category: atp-binding]]
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[[Category: Atp-binding]]
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[[Category: cell cycle]]
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[[Category: Cell cycle]]
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[[Category: cell division]]
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[[Category: Cell division]]
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[[Category: chromosome partition]]
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[[Category: Chromosome partition]]
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[[Category: divisome]]
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[[Category: Divisome]]
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[[Category: dna translocation]]
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[[Category: Dna translocation]]
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[[Category: dna-binding]]
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[[Category: Dna-binding]]
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[[Category: hexameric ring]]
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[[Category: Hexameric ring]]
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[[Category: inner membrane]]
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[[Category: Inner membrane]]
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[[Category: kop]]
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[[Category: Kop]]
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[[Category: membrane]]
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[[Category: Membrane]]
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[[Category: membrane protein]]
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[[Category: Membrane protein]]
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[[Category: nucleotide-binding]]
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[[Category: Nucleotide-binding]]
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[[Category: transmembrane]]
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[[Category: Transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:54:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 03:48:56 2008''
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Revision as of 04:54, 4 May 2008

Image:2iut.gif

Template:STRUCTURE 2iut

P. AERUGINOSA FTSK MOTOR DOMAIN, DIMERIC


Overview

FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.

About this Structure

2IUT is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.

Reference

Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635 Page seeded by OCA on Sun May 4 07:54:39 2008

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OCA

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