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2iuu
From Proteopedia
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[[Image:2iuu.gif|left|200px]] | [[Image:2iuu.gif|left|200px]] | ||
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'''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER''' | '''P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER''' | ||
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[[Category: Sherratt, D J.]] | [[Category: Sherratt, D J.]] | ||
[[Category: Yates, J.]] | [[Category: Yates, J.]] | ||
| - | [[Category: | + | [[Category: Aaa atpase]] |
| - | [[Category: | + | [[Category: Atp-binding]] |
| - | [[Category: | + | [[Category: Cell cycle]] |
| - | [[Category: | + | [[Category: Cell division]] |
| - | [[Category: | + | [[Category: Chromosome partition]] |
| - | [[Category: | + | [[Category: Divisome]] |
| - | [[Category: | + | [[Category: Dna translocation]] |
| - | [[Category: | + | [[Category: Dna-binding]] |
| - | [[Category: | + | [[Category: Hexameric ring]] |
| - | [[Category: | + | [[Category: Inner membrane]] |
| - | [[Category: | + | [[Category: Kop]] |
| - | [[Category: | + | [[Category: Membrane]] |
| - | [[Category: | + | [[Category: Membrane protein]] |
| - | [[Category: | + | [[Category: Nucleotide-binding]] |
| - | [[Category: | + | [[Category: Transmembrane]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun May 4 07:54:48 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:54, 4 May 2008
P. AERUGINOSA FTSK MOTOR DOMAIN, HEXAMER
Overview
FtsK is a DNA translocase that coordinates chromosome segregation and cell division in bacteria. In addition to its role as activator of XerCD site-specific recombination, FtsK can translocate double-stranded DNA (dsDNA) rapidly and directionally and reverse direction. We present crystal structures of the FtsK motor domain monomer, showing that it has a RecA-like core, the FtsK hexamer, and also showing that it is a ring with a large central annulus and a dodecamer consisting of two hexamers, head to head. Electron microscopy (EM) demonstrates the DNA-dependent existence of hexamers in solution and shows that duplex DNA passes through the middle of each ring. Comparison of FtsK monomer structures from two different crystal forms highlights a conformational change that we propose is the structural basis for a rotary inchworm mechanism of DNA translocation.
About this Structure
2IUU is a Single protein structure of sequence from Pseudomonas aeruginosa. Full crystallographic information is available from OCA.
Reference
Double-stranded DNA translocation: structure and mechanism of hexameric FtsK., Massey TH, Mercogliano CP, Yates J, Sherratt DJ, Lowe J, Mol Cell. 2006 Aug;23(4):457-69. PMID:16916635 Page seeded by OCA on Sun May 4 07:54:48 2008
Categories: Pseudomonas aeruginosa | Single protein | Lowe, J. | Massey, T H. | Mercogliano, C P. | Sherratt, D J. | Yates, J. | Aaa atpase | Atp-binding | Cell cycle | Cell division | Chromosome partition | Divisome | Dna translocation | Dna-binding | Hexameric ring | Inner membrane | Kop | Membrane | Membrane protein | Nucleotide-binding | Transmembrane
